Gene recoding by synonymous mutations creates promiscuous intragenic transcription initiation in mycobacteria

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Each genome encodes some codons more frequently than their synonyms (codon usage bias), but codons are also arranged more frequently into specific pairs (codon pair bias). Recoding viral genomes and yeast or bacterial genes with non-optimal codon pairs has been shown to decrease gene expression. Gen...

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Detalles Bibliográficos
Autores principales: Hegelmeyer, Nuri K., Parkin, Lia A., Previti, Mary L., Andrade, Joshua, Utama, Raditya, Sejour, Richard J., Gardin, Justin, Muller, Stephanie, Ketchum, Steven, Yurovsky, Alisa, Futcher, Bruce, Goodwin, Sara, Ueberheide, Beatrix, Seeliger, Jessica C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10653884/
https://www.ncbi.nlm.nih.gov/pubmed/37787543
http://dx.doi.org/10.1128/mbio.00841-23

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