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PKR-mediated stress response enhances dengue and Zika virus replication

The mechanisms by which flaviviruses use non-canonical translation to support their replication in host cells are largely unknown. Here, we investigated how the integrated stress response (ISR), which promotes translational arrest by eIF2ɑ phosphorylation (p-eIF2ɑ), regulates flavivirus replication....

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Detalles Bibliográficos
Autores principales:	Ricciardi-Jorge, Taissa, da Rocha, Edroaldo Lummertz, Gonzalez-Kozlova, Edgar, Rodrigues-Luiz, Gabriela Flavia, Ferguson, Brian J., Sweeney, Trevor, Irigoyen, Nerea, Mansur, Daniel Santos
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10653888/ https://www.ncbi.nlm.nih.gov/pubmed/37732809 http://dx.doi.org/10.1128/mbio.00934-23

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