Recursive genome engineering decodes the evolutionary origin of an essential thymidylate kinase activity in Pseudomonas putida KT2440

Thymidylate kinases (TMPKs) play an essential role in DNA biosynthesis across all domains of life by catalyzing dTMP phosphorylation to dTDP. In Pseudomonas putida KT2440, a model Gram-negative soil bacterium, tmk is disrupted by a 65-kb genomic island (GI), posing questions about the origin of the...

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Detalles Bibliográficos
Autores principales: Wirth, Nicolas T., Rohr, Katja, Danchin, Antoine, Nikel, Pablo I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10653934/
https://www.ncbi.nlm.nih.gov/pubmed/37732760
http://dx.doi.org/10.1128/mbio.01081-23

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