Decitabine disrupts EBV genomic epiallele DNA methylation patterns around CTCF binding sites to increase chromatin accessibility and lytic transcription in gastric cancer

Epstein-Barr virus (EBV) is associated with 10% of human gastric carcinomas, which are distinguished by a CpG island methylator phenotype. In gastric carcinoma tumors and cell lines, the EBV genome also exhibits a high degree of 5-methyl cytosine (5mC) marks, which are propagated by host DNA methylt...

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Detalles Bibliográficos
Autores principales: Preston-Alp, Sarah, Caruso, Lisa Beatrice, Su, Chenhe, Keith, Kelsey, Soldan, Samantha S., Maestri, Davide, Madzo, Jozef, Kossenkov, Andrew, Napoletani, Giorgia, Gewurz, Benjamin, Lieberman, Paul M., Tempera, Italo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10653948/
https://www.ncbi.nlm.nih.gov/pubmed/37606370
http://dx.doi.org/10.1128/mbio.00396-23

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