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Biophysical and structural characterization of the impacts of MET phosphorylation on tepotinib binding

The receptor tyrosine kinase MET is activated by hepatocyte growth factor binding, followed by phosphorylation of the intracellular kinase domain (KD) mainly within the activation loop (A-loop) on Y1234 and Y1235. Dysregulation of MET can lead to both tumor growth and metastatic progression of cance...

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Detalles Bibliográficos
Autores principales:	Grädler, Ulrich, Schwarz, Daniel, Wegener, Ansgar, Eichhorn, Thomas, Bandeiras, Tiago M., Freitas, Micael C., Lammens, Alfred, Ganichkin, Oleg, Augustin, Martin, Minguzzi, Stefano, Becker, Frank, Bomke, Jörg
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10654029/ https://www.ncbi.nlm.nih.gov/pubmed/37806493 http://dx.doi.org/10.1016/j.jbc.2023.105328

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