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Deep mutational scanning of influenza A virus neuraminidase facilitates the identification of drug resistance mutations in vivo
Neuraminidase (NA) is a pivotal surface enzyme and a key therapeutic target in combating the influenza A virus. Its evolution can lead to potential zoonotic transmission, seasonal epidemics, and the emergence of drug-resistant mutants. To gain comprehensive insights into the mutational effects and d...
Autores principales: | Wang, Sihan, Zhang, Tian-hao, Hu, Menglong, Tang, Kejun, Sheng, Li, Hong, Mengying, Chen, Dongdong, Chen, Liubo, Shi, Yuan, Feng, Jun, Qian, Jing, Sun, Lifeng, Ding, Kefeng, Sun, Ren, Du, Yushen |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Microbiology
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10654105/ https://www.ncbi.nlm.nih.gov/pubmed/37772870 http://dx.doi.org/10.1128/msystems.00670-23 |
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