Cargando…
Acetylation and deacetylation of histone in adipocyte differentiation and the potential significance in cancer
Adipocytes are derived from pluripotent mesenchymal stem cells and can develop into several cell types including adipocytes, myocytes, chondrocytes, and osteocytes. Adipocyte differentiation is regulated by a variety of transcription factors and signaling pathways. Various epigenetic factors, partic...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Neoplasia Press
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10654249/ https://www.ncbi.nlm.nih.gov/pubmed/37935080 http://dx.doi.org/10.1016/j.tranon.2023.101815 |
_version_ | 1785136588898959360 |
---|---|
author | Wang, Xiaorui Li, Na Zheng, Minying Yu, Yongjun Zhang, Shiwu |
author_facet | Wang, Xiaorui Li, Na Zheng, Minying Yu, Yongjun Zhang, Shiwu |
author_sort | Wang, Xiaorui |
collection | PubMed |
description | Adipocytes are derived from pluripotent mesenchymal stem cells and can develop into several cell types including adipocytes, myocytes, chondrocytes, and osteocytes. Adipocyte differentiation is regulated by a variety of transcription factors and signaling pathways. Various epigenetic factors, particularly histone modifications, play key roles in adipocyte differentiation and have indispensable functions in altering chromatin conformation. Histone acetylases and deacetylases participate in the regulation of protein acetylation, mediate transcriptional and post-translational modifications, and directly acetylate or deacetylate various transcription factors and regulatory proteins. The adipocyte differentiation of stem cells plays a key role in various metabolic diseases. Cancer stem cells(CSCs) play an important function in cancer metastasis, recurrence, and drug resistance, and have the characteristics of stem cells. They are expressed in various cell lineages, including adipocytes. Recent studies have shown that cancer stem cells that undergo epithelial-mesenchymal transformation can undergo adipocytic differentiation, thereby reducing the degree of malignancy. This opens up new possibilities for cancer treatment. This review summarizes the regulation of acetylation during adipocyte differentiation, involving the functions of histone acetylating and deacetylating enzymes as well as non-histone acetylation modifications. Mechanistic studies on adipogenesis and acetylation during the differentiation of cancer cells into a benign cell phenotype may help identify new targets for cancer treatment. |
format | Online Article Text |
id | pubmed-10654249 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Neoplasia Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-106542492023-11-05 Acetylation and deacetylation of histone in adipocyte differentiation and the potential significance in cancer Wang, Xiaorui Li, Na Zheng, Minying Yu, Yongjun Zhang, Shiwu Transl Oncol Review Adipocytes are derived from pluripotent mesenchymal stem cells and can develop into several cell types including adipocytes, myocytes, chondrocytes, and osteocytes. Adipocyte differentiation is regulated by a variety of transcription factors and signaling pathways. Various epigenetic factors, particularly histone modifications, play key roles in adipocyte differentiation and have indispensable functions in altering chromatin conformation. Histone acetylases and deacetylases participate in the regulation of protein acetylation, mediate transcriptional and post-translational modifications, and directly acetylate or deacetylate various transcription factors and regulatory proteins. The adipocyte differentiation of stem cells plays a key role in various metabolic diseases. Cancer stem cells(CSCs) play an important function in cancer metastasis, recurrence, and drug resistance, and have the characteristics of stem cells. They are expressed in various cell lineages, including adipocytes. Recent studies have shown that cancer stem cells that undergo epithelial-mesenchymal transformation can undergo adipocytic differentiation, thereby reducing the degree of malignancy. This opens up new possibilities for cancer treatment. This review summarizes the regulation of acetylation during adipocyte differentiation, involving the functions of histone acetylating and deacetylating enzymes as well as non-histone acetylation modifications. Mechanistic studies on adipogenesis and acetylation during the differentiation of cancer cells into a benign cell phenotype may help identify new targets for cancer treatment. Neoplasia Press 2023-11-05 /pmc/articles/PMC10654249/ /pubmed/37935080 http://dx.doi.org/10.1016/j.tranon.2023.101815 Text en © 2023 Published by Elsevier Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Wang, Xiaorui Li, Na Zheng, Minying Yu, Yongjun Zhang, Shiwu Acetylation and deacetylation of histone in adipocyte differentiation and the potential significance in cancer |
title | Acetylation and deacetylation of histone in adipocyte differentiation and the potential significance in cancer |
title_full | Acetylation and deacetylation of histone in adipocyte differentiation and the potential significance in cancer |
title_fullStr | Acetylation and deacetylation of histone in adipocyte differentiation and the potential significance in cancer |
title_full_unstemmed | Acetylation and deacetylation of histone in adipocyte differentiation and the potential significance in cancer |
title_short | Acetylation and deacetylation of histone in adipocyte differentiation and the potential significance in cancer |
title_sort | acetylation and deacetylation of histone in adipocyte differentiation and the potential significance in cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10654249/ https://www.ncbi.nlm.nih.gov/pubmed/37935080 http://dx.doi.org/10.1016/j.tranon.2023.101815 |
work_keys_str_mv | AT wangxiaorui acetylationanddeacetylationofhistoneinadipocytedifferentiationandthepotentialsignificanceincancer AT lina acetylationanddeacetylationofhistoneinadipocytedifferentiationandthepotentialsignificanceincancer AT zhengminying acetylationanddeacetylationofhistoneinadipocytedifferentiationandthepotentialsignificanceincancer AT yuyongjun acetylationanddeacetylationofhistoneinadipocytedifferentiationandthepotentialsignificanceincancer AT zhangshiwu acetylationanddeacetylationofhistoneinadipocytedifferentiationandthepotentialsignificanceincancer |