Repression of LSD1 potentiates homologous recombination-proficient ovarian cancer to PARP inhibitors through down-regulation of BRCA1/2 and RAD51

Poly (ADP-ribose) polymerase inhibitors (PARPi) are selectively active in ovarian cancer (OC) with homologous recombination (HR) deficiency (HRD) caused by mutations in BRCA1/2 and other DNA repair pathway members. We sought molecular targeted therapy that induce HRD in HR-proficient cells to induce...

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Detalles Bibliográficos
Autores principales: Tao, Lei, Zhou, Yue, Pan, Xiangyu, Luo, Yuan, Qiu, Jiahao, Zhou, Xia, Chen, Zhiqian, Li, Yan, Xu, Lian, Zhou, Yang, Zuo, Zeping, Liu, Chunqi, Wang, Liang, Liu, Xiaocong, Tian, Xinyu, Su, Na, Yang, Zhengnan, Zhang, Yu, Gou, Kun, Sang, Na, Liu, Huan, Zou, Jiao, Xiao, Yuzhou, Zhong, Xi, Xu, Jing, Yang, Xinyu, Xiao, Kai, Liu, Yanyang, Yang, Shengyong, Peng, Yong, Han, Junhong, Cen, Xiaobo, Zhao, Yinglan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10654398/
https://www.ncbi.nlm.nih.gov/pubmed/37973845
http://dx.doi.org/10.1038/s41467-023-42850-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10654398/
https://www.ncbi.nlm.nih.gov/pubmed/37973845
http://dx.doi.org/10.1038/s41467-023-42850-x

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