Activation of Lysosomal Function Ameliorates Amyloid-β-Induced Tight Junction Disruption in the Retinal Pigment Epithelium

Accumulation of pathogenic amyloid-β disrupts the tight junction of retinal pigment epithelium (RPE), one of its senescence-like structural alterations. In the clearance of amyloid-β, the autophagy-lysosome pathway plays the crucial role. In this context, mammalian target of rapamycin (mTOR) inhibit...

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Detalles Bibliográficos
Autores principales: Jo, Dong Hyun, Lee, Su Hyun, Jeon, Minsol, Cho, Chang Sik, Kim, Da-Eun, Kim, Hyunkyung, Kim, Jeong Hun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Molecular and Cellular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10654459/
https://www.ncbi.nlm.nih.gov/pubmed/37968982
http://dx.doi.org/10.14348/molcells.2023.0056

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