Ergolide mediates anti-cancer effects on metastatic uveal melanoma cells and modulates their cellular and extracellular vesicle proteomes

BACKGROUND: Uveal melanoma is a poor prognosis cancer. Ergolide, a sesquiterpene lactone isolated from Inula Brittanica, exerts anti-cancer properties. The objective of this study was to 1) evaluate whether ergolide reduced metastatic uveal melanoma (MUM) cell survival/viability in vitro and in vivo...

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Detalles Bibliográficos
Autores principales: Sundaramurthi, Husvinee, Tonelotto, Valentina, Wynne, Kieran, O'Connell, Fiona, O’Reilly, Eve, Costa-Garcia, Marcel, Kovácsházi, Csenger, Kittel, Agnes, Marcone, Simone, Blanco, Alfonso, Pallinger, Eva, Hambalkó, Szabolcs, Piulats Rodriguez, Jose Maria, Ferdinandy, Péter, O'Sullivan, Jacintha, Matallanas, David, Jensen, Lasse D., Giricz, Zoltán, Kennedy, Breandán N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10654492/
https://www.ncbi.nlm.nih.gov/pubmed/37981907
http://dx.doi.org/10.12688/openreseurope.15973.2

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