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Optimization, characterization, and follicular targeting assessment of tretinoin and bicalutamide loaded niosomes

Acne vulgaris, a prevalent skin disorder among teenagers and young adults, can have numerous psychological consequences. Topical treatment of acne would be advantageous by reducing the risk of systemic adverse drug reactions. However, the major challenge would be skin penetration through the stratum...

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Autores principales: Ghasemiyeh, Parisa, Moradishooli, Fatemeh, Daneshamouz, Saeid, Heidari, Reza, Niroumand, Uranous, Mohammadi-Samani, Soliman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10654571/
https://www.ncbi.nlm.nih.gov/pubmed/37973805
http://dx.doi.org/10.1038/s41598-023-47302-6
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author Ghasemiyeh, Parisa
Moradishooli, Fatemeh
Daneshamouz, Saeid
Heidari, Reza
Niroumand, Uranous
Mohammadi-Samani, Soliman
author_facet Ghasemiyeh, Parisa
Moradishooli, Fatemeh
Daneshamouz, Saeid
Heidari, Reza
Niroumand, Uranous
Mohammadi-Samani, Soliman
author_sort Ghasemiyeh, Parisa
collection PubMed
description Acne vulgaris, a prevalent skin disorder among teenagers and young adults, can have numerous psychological consequences. Topical treatment of acne would be advantageous by reducing the risk of systemic adverse drug reactions. However, the major challenge would be skin penetration through the stratum corneum. Therefore, during this study, tretinoin (TRT) and bicalutamide (BCT) loaded niosomes with follicular targeting potential were fabricated through the thin film hydration technique. Formulation optimization was performed using the Design-Expert software and optimum formulation was characterized in terms of particle size, zeta potential, transmission electron microscopy, drug loading, and differential scanning calorimetry. In vivo follicular targeting was assessed using rhodamine B-loaded niosomes to follow the skin penetration pathways. The results showed that, the optimum formulation was spherical in shape and had an average diameter of 319.20 ± 18.50 nm and a zeta potential of − 29.70 ± 0.36 mV. Furthermore, entrapment efficiencies were 94.63 ± 0.50% and > 99% and loading capacities were 1.40 ± 0.01% and 1.48 ± 0.00% for BCT and TRT, respectively. According to the animal study results, the prepared niosomes with an average diameter of about 300 nm showed significant accumulation in hair follicles. It seems that the designed niosomal BCT-TRT co-delivery system would be promising in acne management with follicular targeting potential.
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spelling pubmed-106545712023-11-16 Optimization, characterization, and follicular targeting assessment of tretinoin and bicalutamide loaded niosomes Ghasemiyeh, Parisa Moradishooli, Fatemeh Daneshamouz, Saeid Heidari, Reza Niroumand, Uranous Mohammadi-Samani, Soliman Sci Rep Article Acne vulgaris, a prevalent skin disorder among teenagers and young adults, can have numerous psychological consequences. Topical treatment of acne would be advantageous by reducing the risk of systemic adverse drug reactions. However, the major challenge would be skin penetration through the stratum corneum. Therefore, during this study, tretinoin (TRT) and bicalutamide (BCT) loaded niosomes with follicular targeting potential were fabricated through the thin film hydration technique. Formulation optimization was performed using the Design-Expert software and optimum formulation was characterized in terms of particle size, zeta potential, transmission electron microscopy, drug loading, and differential scanning calorimetry. In vivo follicular targeting was assessed using rhodamine B-loaded niosomes to follow the skin penetration pathways. The results showed that, the optimum formulation was spherical in shape and had an average diameter of 319.20 ± 18.50 nm and a zeta potential of − 29.70 ± 0.36 mV. Furthermore, entrapment efficiencies were 94.63 ± 0.50% and > 99% and loading capacities were 1.40 ± 0.01% and 1.48 ± 0.00% for BCT and TRT, respectively. According to the animal study results, the prepared niosomes with an average diameter of about 300 nm showed significant accumulation in hair follicles. It seems that the designed niosomal BCT-TRT co-delivery system would be promising in acne management with follicular targeting potential. Nature Publishing Group UK 2023-11-16 /pmc/articles/PMC10654571/ /pubmed/37973805 http://dx.doi.org/10.1038/s41598-023-47302-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Ghasemiyeh, Parisa
Moradishooli, Fatemeh
Daneshamouz, Saeid
Heidari, Reza
Niroumand, Uranous
Mohammadi-Samani, Soliman
Optimization, characterization, and follicular targeting assessment of tretinoin and bicalutamide loaded niosomes
title Optimization, characterization, and follicular targeting assessment of tretinoin and bicalutamide loaded niosomes
title_full Optimization, characterization, and follicular targeting assessment of tretinoin and bicalutamide loaded niosomes
title_fullStr Optimization, characterization, and follicular targeting assessment of tretinoin and bicalutamide loaded niosomes
title_full_unstemmed Optimization, characterization, and follicular targeting assessment of tretinoin and bicalutamide loaded niosomes
title_short Optimization, characterization, and follicular targeting assessment of tretinoin and bicalutamide loaded niosomes
title_sort optimization, characterization, and follicular targeting assessment of tretinoin and bicalutamide loaded niosomes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10654571/
https://www.ncbi.nlm.nih.gov/pubmed/37973805
http://dx.doi.org/10.1038/s41598-023-47302-6
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