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Classification, function, and advances in tsRNA in non-neoplastic diseases
tRNA-derived small RNAs (tsRNAs) are non-coding small RNAs produced by specific endonucleases following the processing and splicing of precursor or mature tRNAs upon starvation, oxidative stress, hypoxia, and other adverse conditions. tRNAs are classified into two major categories, tRNA fragments (t...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10654580/ https://www.ncbi.nlm.nih.gov/pubmed/37973899 http://dx.doi.org/10.1038/s41419-023-06250-9 |
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author | Zhang, Liou Liu, Jie Hou, Yang |
author_facet | Zhang, Liou Liu, Jie Hou, Yang |
author_sort | Zhang, Liou |
collection | PubMed |
description | tRNA-derived small RNAs (tsRNAs) are non-coding small RNAs produced by specific endonucleases following the processing and splicing of precursor or mature tRNAs upon starvation, oxidative stress, hypoxia, and other adverse conditions. tRNAs are classified into two major categories, tRNA fragments (tRFs) and tRNA-derived stress-induced small RNAs (tiRNAs), based on differences in splice sites. With the development of high-throughput sequencing technologies in recent years, tsRNAs have been found to have important biological functions, including inhibition of apoptosis, epigenetic regulation, cell–cell communication, translation, and regulation of gene expression. Additionally, these molecules have been found to be aberrantly expressed in various diseases and to be involved in several pathological processes. In this article, the classification and nomenclature, biological functions, and potential use of tsRNAs as diagnostic biomarkers and therapeutic targets in non-neoplastic diseases are reviewed. Although tsRNA research is at its infancy, their potential in the treatment of non-tumor diseases warrants further investigation. |
format | Online Article Text |
id | pubmed-10654580 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-106545802023-11-16 Classification, function, and advances in tsRNA in non-neoplastic diseases Zhang, Liou Liu, Jie Hou, Yang Cell Death Dis Review Article tRNA-derived small RNAs (tsRNAs) are non-coding small RNAs produced by specific endonucleases following the processing and splicing of precursor or mature tRNAs upon starvation, oxidative stress, hypoxia, and other adverse conditions. tRNAs are classified into two major categories, tRNA fragments (tRFs) and tRNA-derived stress-induced small RNAs (tiRNAs), based on differences in splice sites. With the development of high-throughput sequencing technologies in recent years, tsRNAs have been found to have important biological functions, including inhibition of apoptosis, epigenetic regulation, cell–cell communication, translation, and regulation of gene expression. Additionally, these molecules have been found to be aberrantly expressed in various diseases and to be involved in several pathological processes. In this article, the classification and nomenclature, biological functions, and potential use of tsRNAs as diagnostic biomarkers and therapeutic targets in non-neoplastic diseases are reviewed. Although tsRNA research is at its infancy, their potential in the treatment of non-tumor diseases warrants further investigation. Nature Publishing Group UK 2023-11-16 /pmc/articles/PMC10654580/ /pubmed/37973899 http://dx.doi.org/10.1038/s41419-023-06250-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Article Zhang, Liou Liu, Jie Hou, Yang Classification, function, and advances in tsRNA in non-neoplastic diseases |
title | Classification, function, and advances in tsRNA in non-neoplastic diseases |
title_full | Classification, function, and advances in tsRNA in non-neoplastic diseases |
title_fullStr | Classification, function, and advances in tsRNA in non-neoplastic diseases |
title_full_unstemmed | Classification, function, and advances in tsRNA in non-neoplastic diseases |
title_short | Classification, function, and advances in tsRNA in non-neoplastic diseases |
title_sort | classification, function, and advances in tsrna in non-neoplastic diseases |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10654580/ https://www.ncbi.nlm.nih.gov/pubmed/37973899 http://dx.doi.org/10.1038/s41419-023-06250-9 |
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