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Aurora B kinase erases monopolar microtubule-kinetochore arrays at the meiosis I-II transition
During meiosis, faithful chromosome segregation requires monopolar spindle microtubule-kinetochore arrays in MI to segregate homologous chromosomes, but bipolar in MII to segregate sister chromatids. Using fission yeasts, we found that the universal Aurora B kinase localizes to kinetochores in metap...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10654595/ https://www.ncbi.nlm.nih.gov/pubmed/38026180 http://dx.doi.org/10.1016/j.isci.2023.108339 |
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author | Villa-Consuegra, Sergio Tallada, Víctor A. Jimenez, Juan |
author_facet | Villa-Consuegra, Sergio Tallada, Víctor A. Jimenez, Juan |
author_sort | Villa-Consuegra, Sergio |
collection | PubMed |
description | During meiosis, faithful chromosome segregation requires monopolar spindle microtubule-kinetochore arrays in MI to segregate homologous chromosomes, but bipolar in MII to segregate sister chromatids. Using fission yeasts, we found that the universal Aurora B kinase localizes to kinetochores in metaphase I and in the mid-spindle during anaphase I, as in mitosis; but in the absence of an intervening S phase, the importin α Imp1 propitiates its release from the spindle midzone to re-localize at kinetochores during meiotic interkinesis. We show that “error-correction” activity of kinetochore re-localized Aurora B becomes essential to erase monopolar arrangements from anaphase I, a prerequisite to satisfy the spindle assembly checkpoint (SAC) and to generate proper bipolar arrays at the onset of MII. This microtubule-kinetochore resetting activity of Aurora B at the MI-MII transition is required to prevent chromosome missegregation in meiosis II, a type of error often associated with birth defects and infertility in humans. |
format | Online Article Text |
id | pubmed-10654595 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-106545952023-10-27 Aurora B kinase erases monopolar microtubule-kinetochore arrays at the meiosis I-II transition Villa-Consuegra, Sergio Tallada, Víctor A. Jimenez, Juan iScience Article During meiosis, faithful chromosome segregation requires monopolar spindle microtubule-kinetochore arrays in MI to segregate homologous chromosomes, but bipolar in MII to segregate sister chromatids. Using fission yeasts, we found that the universal Aurora B kinase localizes to kinetochores in metaphase I and in the mid-spindle during anaphase I, as in mitosis; but in the absence of an intervening S phase, the importin α Imp1 propitiates its release from the spindle midzone to re-localize at kinetochores during meiotic interkinesis. We show that “error-correction” activity of kinetochore re-localized Aurora B becomes essential to erase monopolar arrangements from anaphase I, a prerequisite to satisfy the spindle assembly checkpoint (SAC) and to generate proper bipolar arrays at the onset of MII. This microtubule-kinetochore resetting activity of Aurora B at the MI-MII transition is required to prevent chromosome missegregation in meiosis II, a type of error often associated with birth defects and infertility in humans. Elsevier 2023-10-27 /pmc/articles/PMC10654595/ /pubmed/38026180 http://dx.doi.org/10.1016/j.isci.2023.108339 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Villa-Consuegra, Sergio Tallada, Víctor A. Jimenez, Juan Aurora B kinase erases monopolar microtubule-kinetochore arrays at the meiosis I-II transition |
title | Aurora B kinase erases monopolar microtubule-kinetochore arrays at the meiosis I-II transition |
title_full | Aurora B kinase erases monopolar microtubule-kinetochore arrays at the meiosis I-II transition |
title_fullStr | Aurora B kinase erases monopolar microtubule-kinetochore arrays at the meiosis I-II transition |
title_full_unstemmed | Aurora B kinase erases monopolar microtubule-kinetochore arrays at the meiosis I-II transition |
title_short | Aurora B kinase erases monopolar microtubule-kinetochore arrays at the meiosis I-II transition |
title_sort | aurora b kinase erases monopolar microtubule-kinetochore arrays at the meiosis i-ii transition |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10654595/ https://www.ncbi.nlm.nih.gov/pubmed/38026180 http://dx.doi.org/10.1016/j.isci.2023.108339 |
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