Circadian disturbances and frailty risk in older adults

Frailty is characterized by diminished resilience to stressor events. It is associated with adverse future health outcomes and impedes healthy aging. The circadian system orchestrates ~24-h rhythms in bodily functions in synchrony with the day-night cycle, and disturbed circadian regulation plays an...

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Autores principales: Cai, Ruixue, Gao, Lei, Gao, Chenlu, Yu, Lei, Zheng, Xi, Bennett, David A., Buchman, Aron S., Hu, Kun, Li, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10654720/
https://www.ncbi.nlm.nih.gov/pubmed/37973796
http://dx.doi.org/10.1038/s41467-023-42727-z
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author Cai, Ruixue
Gao, Lei
Gao, Chenlu
Yu, Lei
Zheng, Xi
Bennett, David A.
Buchman, Aron S.
Hu, Kun
Li, Peng
author_facet Cai, Ruixue
Gao, Lei
Gao, Chenlu
Yu, Lei
Zheng, Xi
Bennett, David A.
Buchman, Aron S.
Hu, Kun
Li, Peng
author_sort Cai, Ruixue
collection PubMed
description Frailty is characterized by diminished resilience to stressor events. It is associated with adverse future health outcomes and impedes healthy aging. The circadian system orchestrates ~24-h rhythms in bodily functions in synchrony with the day-night cycle, and disturbed circadian regulation plays an important role in many age-related health consequences. We investigated prospective associations of circadian disturbances with incident frailty in over 1000 older adults who had been followed annually for up to 16 years. We found that decreased rhythm strength, reduced stability, or increased variation were associated with a higher risk of incident frailty and faster progress of frailty over time. Perturbed circadian rest-activity rhythms may be an early sign or risk factor for frailty in older adults.
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spelling pubmed-106547202023-11-16 Circadian disturbances and frailty risk in older adults Cai, Ruixue Gao, Lei Gao, Chenlu Yu, Lei Zheng, Xi Bennett, David A. Buchman, Aron S. Hu, Kun Li, Peng Nat Commun Article Frailty is characterized by diminished resilience to stressor events. It is associated with adverse future health outcomes and impedes healthy aging. The circadian system orchestrates ~24-h rhythms in bodily functions in synchrony with the day-night cycle, and disturbed circadian regulation plays an important role in many age-related health consequences. We investigated prospective associations of circadian disturbances with incident frailty in over 1000 older adults who had been followed annually for up to 16 years. We found that decreased rhythm strength, reduced stability, or increased variation were associated with a higher risk of incident frailty and faster progress of frailty over time. Perturbed circadian rest-activity rhythms may be an early sign or risk factor for frailty in older adults. Nature Publishing Group UK 2023-11-16 /pmc/articles/PMC10654720/ /pubmed/37973796 http://dx.doi.org/10.1038/s41467-023-42727-z Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Cai, Ruixue
Gao, Lei
Gao, Chenlu
Yu, Lei
Zheng, Xi
Bennett, David A.
Buchman, Aron S.
Hu, Kun
Li, Peng
Circadian disturbances and frailty risk in older adults
title Circadian disturbances and frailty risk in older adults
title_full Circadian disturbances and frailty risk in older adults
title_fullStr Circadian disturbances and frailty risk in older adults
title_full_unstemmed Circadian disturbances and frailty risk in older adults
title_short Circadian disturbances and frailty risk in older adults
title_sort circadian disturbances and frailty risk in older adults
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10654720/
https://www.ncbi.nlm.nih.gov/pubmed/37973796
http://dx.doi.org/10.1038/s41467-023-42727-z
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