Flavones provide resistance to DUX4-induced toxicity via an mTor-independent mechanism

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Facioscapulohumeral muscular dystrophy (FSHD) is among the most common of the muscular dystrophies, affecting nearly 1 in 8000 individuals, and is a cause of profound disability. Genetically, FSHD is linked to the contraction and/or epigenetic de-repression of the D4Z4 repeat array on chromosome 4,...

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Detalles Bibliográficos
Autores principales: Cohen, Justin, Huang, Shushu, Koczwara, Katherine E., Woods, Kristen T., Ho, Vincent, Woodman, Keryn G., Arbiser, Jack L., Daman, Katelyn, Lek, Monkol, Emerson, Charles P., DeSimone, Alec M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10654915/
https://www.ncbi.nlm.nih.gov/pubmed/37973788
http://dx.doi.org/10.1038/s41419-023-06257-2

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