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Clinical complications after a traumatic brain injury and its relation with brain biomarkers

We aimed to find out which are the most frequent complications for patients who suffer a traumatic brain injury (TBI) and its relation with brain biomarker levels. We conducted a hospital cohort study with patients who attended the Hospital Emergency Department between 1 June 2018 and 31 December 20...

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Autores principales: Yuguero, Oriol, Bernal, Maria, Farré, Joan, Martinez-Alonso, Montserrat, Vena, Ana, Purroy, Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10654919/
https://www.ncbi.nlm.nih.gov/pubmed/37973882
http://dx.doi.org/10.1038/s41598-023-47267-6
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author Yuguero, Oriol
Bernal, Maria
Farré, Joan
Martinez-Alonso, Montserrat
Vena, Ana
Purroy, Francisco
author_facet Yuguero, Oriol
Bernal, Maria
Farré, Joan
Martinez-Alonso, Montserrat
Vena, Ana
Purroy, Francisco
author_sort Yuguero, Oriol
collection PubMed
description We aimed to find out which are the most frequent complications for patients who suffer a traumatic brain injury (TBI) and its relation with brain biomarker levels. We conducted a hospital cohort study with patients who attended the Hospital Emergency Department between 1 June 2018 and 31 December 2020. Different variables were collected such as biomarkers levels after 6 h and 12 h of TBI (S100, NSE, UCHL1 and GFAP), clinical and sociodemographic variables, complementary tests, and complications 48 h and 7 days after TBI. Qualitative variables were analysed with Pearson’s chi-square test, and quantitative variables with the Mann–Whitney U test. A multivariate logistic regression model for the existence of complications one week after discharge was performed to assess the discriminatory capacity of the clinical variables. A total of 51 controls and 540 patients were included in this study. In the TBI group, the mean age was 83 years, and 53.9% of the patients were male. Complications at seven days were associated with the severity of TBI (p < 0.05) and the number of platelets (p = 0.016). All biomarkers except GFAP showed significant differences in their distribution of values according to gender, with significantly higher values of the three biomarkers for women with respect to men. Patients with complications presented significantly higher S100 values (p < 0.05). The patient’s baseline status, the severity of the TBI and the S100 levels can be very important elements in determining whether a patient may develop complications in the few hours after TBI.
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spelling pubmed-106549192023-11-16 Clinical complications after a traumatic brain injury and its relation with brain biomarkers Yuguero, Oriol Bernal, Maria Farré, Joan Martinez-Alonso, Montserrat Vena, Ana Purroy, Francisco Sci Rep Article We aimed to find out which are the most frequent complications for patients who suffer a traumatic brain injury (TBI) and its relation with brain biomarker levels. We conducted a hospital cohort study with patients who attended the Hospital Emergency Department between 1 June 2018 and 31 December 2020. Different variables were collected such as biomarkers levels after 6 h and 12 h of TBI (S100, NSE, UCHL1 and GFAP), clinical and sociodemographic variables, complementary tests, and complications 48 h and 7 days after TBI. Qualitative variables were analysed with Pearson’s chi-square test, and quantitative variables with the Mann–Whitney U test. A multivariate logistic regression model for the existence of complications one week after discharge was performed to assess the discriminatory capacity of the clinical variables. A total of 51 controls and 540 patients were included in this study. In the TBI group, the mean age was 83 years, and 53.9% of the patients were male. Complications at seven days were associated with the severity of TBI (p < 0.05) and the number of platelets (p = 0.016). All biomarkers except GFAP showed significant differences in their distribution of values according to gender, with significantly higher values of the three biomarkers for women with respect to men. Patients with complications presented significantly higher S100 values (p < 0.05). The patient’s baseline status, the severity of the TBI and the S100 levels can be very important elements in determining whether a patient may develop complications in the few hours after TBI. Nature Publishing Group UK 2023-11-16 /pmc/articles/PMC10654919/ /pubmed/37973882 http://dx.doi.org/10.1038/s41598-023-47267-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Yuguero, Oriol
Bernal, Maria
Farré, Joan
Martinez-Alonso, Montserrat
Vena, Ana
Purroy, Francisco
Clinical complications after a traumatic brain injury and its relation with brain biomarkers
title Clinical complications after a traumatic brain injury and its relation with brain biomarkers
title_full Clinical complications after a traumatic brain injury and its relation with brain biomarkers
title_fullStr Clinical complications after a traumatic brain injury and its relation with brain biomarkers
title_full_unstemmed Clinical complications after a traumatic brain injury and its relation with brain biomarkers
title_short Clinical complications after a traumatic brain injury and its relation with brain biomarkers
title_sort clinical complications after a traumatic brain injury and its relation with brain biomarkers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10654919/
https://www.ncbi.nlm.nih.gov/pubmed/37973882
http://dx.doi.org/10.1038/s41598-023-47267-6
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