Xanthine-based photoaffinity probes allow assessment of ligand engagement by TRPC5 channels

TRPC1/4/5 cation channels are emerging drug targets for the treatment of, amongst others, central nervous system (CNS) disorders, kidney disease, and cardiovascular and metabolic disease. Various small-molecule TRPC1/4/5 modulators have been reported, including highly potent xanthine derivatives tha...

Descripción completa

Detalles Bibliográficos
Autores principales: Bauer, Claudia C., Minard, Aisling, Pickles, Isabelle B., Simmons, Katie J., Chuntharpursat-Bon, Eulashini, Burnham, Matthew P., Kapur, Nikil, Beech, David J., Muench, Stephen P., Wright, Megan H., Warriner, Stuart L., Bon, Robin S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10655067/
http://dx.doi.org/10.1039/d0cb00126k

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10655067/
http://dx.doi.org/10.1039/d0cb00126k

Ejemplares similares