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Xanthine-based photoaffinity probes allow assessment of ligand engagement by TRPC5 channels

TRPC1/4/5 cation channels are emerging drug targets for the treatment of, amongst others, central nervous system (CNS) disorders, kidney disease, and cardiovascular and metabolic disease. Various small-molecule TRPC1/4/5 modulators have been reported, including highly potent xanthine derivatives tha...

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Detalles Bibliográficos
Autores principales:	Bauer, Claudia C., Minard, Aisling, Pickles, Isabelle B., Simmons, Katie J., Chuntharpursat-Bon, Eulashini, Burnham, Matthew P., Kapur, Nikil, Beech, David J., Muench, Stephen P., Wright, Megan H., Warriner, Stuart L., Bon, Robin S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	RSC 2020
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10655067/ http://dx.doi.org/10.1039/d0cb00126k

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