Multidrug-resistant Corynebacterium diphtheriae in people with travel history from West Africa to France, March to September 2023

We describe 10 unlinked cases of Corynebacterium diphtheriae infection (nine cutaneous, one respiratory) in France in 2023 in persons travelling from Guinea, Mali, Senegal, Niger or Nigeria and Central African Republic. Four isolates were toxigenic. Seven genomically unrelated isolates were multidru...

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Detalles Bibliográficos
Autores principales: Brémont, Sylvie, Passet, Virginie, Hennart, Mélanie, Fonteneau, Laure, Toubiana, Julie, Badell, Edgar, Brisse, Sylvain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2023
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10655204/
https://www.ncbi.nlm.nih.gov/pubmed/37971662
http://dx.doi.org/10.2807/1560-7917.ES.2023.28.46.2300615
Descripción
Sumario:We describe 10 unlinked cases of Corynebacterium diphtheriae infection (nine cutaneous, one respiratory) in France in 2023 in persons travelling from Guinea, Mali, Senegal, Niger or Nigeria and Central African Republic. Four isolates were toxigenic. Seven genomically unrelated isolates were multidrug-resistant, including a toxigenic respiratory isolate with high-level resistance to macrolides and beta-lactams. The high rates of resistance, including against first-line agents, call for further microbiological investigations to guide clinical management and public health response in ongoing West African outbreaks.

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