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Association of anticardiolipin antibodies with epilepsy in children
We investigated the association of anticardiolipin antibodies (aCL) with epilepsy development and characteristics in children. This prospective case-control study included 40 epileptic children and 40 sex- and age-matched controls. Epileptic children had higher levels of aCL compared to healthy cont...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10655207/ https://www.ncbi.nlm.nih.gov/pubmed/37981986 http://dx.doi.org/10.24294/ti.v7.i1.2021 |
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author | Shiva, Shadi Khanzadeh, Shokoufeh Rashidi, Farzad Lucke-Wold, Brandon |
author_facet | Shiva, Shadi Khanzadeh, Shokoufeh Rashidi, Farzad Lucke-Wold, Brandon |
author_sort | Shiva, Shadi |
collection | PubMed |
description | We investigated the association of anticardiolipin antibodies (aCL) with epilepsy development and characteristics in children. This prospective case-control study included 40 epileptic children and 40 sex- and age-matched controls. Epileptic children had higher levels of aCL compared to healthy controls (5.66 ± 5.41 versus 2.37 ± 2.28; p value = 0.001). The novel finding of elevated levels of aCL predicted response to IVIg therapy (p value = 0.009). Patients with normal EEG had lower levels of aCL compared to those with EEG abnormal findings (p value = 0.015). Patients with the combined type of epilepsy had statistically significant higher levels of aCL compared to other types (p value = 0.046). Also, aCL levels were correlated with seizure frequency (p value = 0.019). These results declare the possible involvement of such antibodies in the onset or pathogenesis of epilepsy. Screening for aCL may help in the timely diagnosis of epilepsy and initiation of appropriate treatment. |
format | Online Article Text |
id | pubmed-10655207 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
record_format | MEDLINE/PubMed |
spelling | pubmed-106552072023-11-17 Association of anticardiolipin antibodies with epilepsy in children Shiva, Shadi Khanzadeh, Shokoufeh Rashidi, Farzad Lucke-Wold, Brandon Trends Immunother Article We investigated the association of anticardiolipin antibodies (aCL) with epilepsy development and characteristics in children. This prospective case-control study included 40 epileptic children and 40 sex- and age-matched controls. Epileptic children had higher levels of aCL compared to healthy controls (5.66 ± 5.41 versus 2.37 ± 2.28; p value = 0.001). The novel finding of elevated levels of aCL predicted response to IVIg therapy (p value = 0.009). Patients with normal EEG had lower levels of aCL compared to those with EEG abnormal findings (p value = 0.015). Patients with the combined type of epilepsy had statistically significant higher levels of aCL compared to other types (p value = 0.046). Also, aCL levels were correlated with seizure frequency (p value = 0.019). These results declare the possible involvement of such antibodies in the onset or pathogenesis of epilepsy. Screening for aCL may help in the timely diagnosis of epilepsy and initiation of appropriate treatment. 2023 2023-07-03 /pmc/articles/PMC10655207/ /pubmed/37981986 http://dx.doi.org/10.24294/ti.v7.i1.2021 Text en https://creativecommons.org/licenses/by-nc/4.0/This work is licensed under the Creative Commons Attribution-Non-Commercial 4.0 International License (CC BY-NC 4.0). https://creativecommons.org/licenses/by-nc/4.0/ |
spellingShingle | Article Shiva, Shadi Khanzadeh, Shokoufeh Rashidi, Farzad Lucke-Wold, Brandon Association of anticardiolipin antibodies with epilepsy in children |
title | Association of anticardiolipin antibodies with epilepsy in children |
title_full | Association of anticardiolipin antibodies with epilepsy in children |
title_fullStr | Association of anticardiolipin antibodies with epilepsy in children |
title_full_unstemmed | Association of anticardiolipin antibodies with epilepsy in children |
title_short | Association of anticardiolipin antibodies with epilepsy in children |
title_sort | association of anticardiolipin antibodies with epilepsy in children |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10655207/ https://www.ncbi.nlm.nih.gov/pubmed/37981986 http://dx.doi.org/10.24294/ti.v7.i1.2021 |
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