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Change in Prevalence of Meningitis among Children with Febrile Seizure after the Pentavalent Vaccination

INTRODUCTION: One of the most significant current discussions in pediatrics is whether lumbar puncture (LP) should be performed in children with febrile seizure (FS) as in the past. OBJECTIVES: We compared the prevalence of meningitis among FS children before and after the pentavalent vaccine to det...

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Autores principales: Shiva, Shadi, Khanzadeh, Shokoufeh, Shohanizad, Vahid, Ghaedi, Arshin, Lucke-Wold, Brandon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10655218/
https://www.ncbi.nlm.nih.gov/pubmed/37981976
http://dx.doi.org/10.33696/neurol.4.079
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author Shiva, Shadi
Khanzadeh, Shokoufeh
Shohanizad, Vahid
Ghaedi, Arshin
Lucke-Wold, Brandon
author_facet Shiva, Shadi
Khanzadeh, Shokoufeh
Shohanizad, Vahid
Ghaedi, Arshin
Lucke-Wold, Brandon
author_sort Shiva, Shadi
collection PubMed
description INTRODUCTION: One of the most significant current discussions in pediatrics is whether lumbar puncture (LP) should be performed in children with febrile seizure (FS) as in the past. OBJECTIVES: We compared the prevalence of meningitis among FS children before and after the pentavalent vaccine to determine the importance of the LP in these children METHODS: We performed a retrospective cross-sectional study on the prevalence and etiology of bacterial meningitis (BM) in 1314 children with FS before and after pentavalent vaccination. RESULTS: We found that complex FS was more prevalent in patients aged under 12 months compared to other patients. The peak incidence of aseptic meningitis and BM was in the age group of 12- to 18- and 18- to 36-month-old, respectively (P value <0.001 and <0.05, respectively). Children with complex FS had a significantly higher rate of BM and a lower rate of seizure recurrence than those with simple FS (P value <0.05). There was a significant relationship between getting the pentavalent vaccine and reducing the prevalence of BM and Hib-induced BM, but no SP-induced BM (P value <0.05 and 0.05 and 0.104, respectively). CONCLUSION: This study offers some insights into the effectiveness of the pentavalent vaccine. In addition, the low prevalence of BM in vaccinated FS cases does not support strong recommendations for LP in FS children.
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spelling pubmed-106552182023-11-17 Change in Prevalence of Meningitis among Children with Febrile Seizure after the Pentavalent Vaccination Shiva, Shadi Khanzadeh, Shokoufeh Shohanizad, Vahid Ghaedi, Arshin Lucke-Wold, Brandon J Exp Neurol Article INTRODUCTION: One of the most significant current discussions in pediatrics is whether lumbar puncture (LP) should be performed in children with febrile seizure (FS) as in the past. OBJECTIVES: We compared the prevalence of meningitis among FS children before and after the pentavalent vaccine to determine the importance of the LP in these children METHODS: We performed a retrospective cross-sectional study on the prevalence and etiology of bacterial meningitis (BM) in 1314 children with FS before and after pentavalent vaccination. RESULTS: We found that complex FS was more prevalent in patients aged under 12 months compared to other patients. The peak incidence of aseptic meningitis and BM was in the age group of 12- to 18- and 18- to 36-month-old, respectively (P value <0.001 and <0.05, respectively). Children with complex FS had a significantly higher rate of BM and a lower rate of seizure recurrence than those with simple FS (P value <0.05). There was a significant relationship between getting the pentavalent vaccine and reducing the prevalence of BM and Hib-induced BM, but no SP-induced BM (P value <0.05 and 0.05 and 0.104, respectively). CONCLUSION: This study offers some insights into the effectiveness of the pentavalent vaccine. In addition, the low prevalence of BM in vaccinated FS cases does not support strong recommendations for LP in FS children. 2023 /pmc/articles/PMC10655218/ /pubmed/37981976 http://dx.doi.org/10.33696/neurol.4.079 Text en https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Article
Shiva, Shadi
Khanzadeh, Shokoufeh
Shohanizad, Vahid
Ghaedi, Arshin
Lucke-Wold, Brandon
Change in Prevalence of Meningitis among Children with Febrile Seizure after the Pentavalent Vaccination
title Change in Prevalence of Meningitis among Children with Febrile Seizure after the Pentavalent Vaccination
title_full Change in Prevalence of Meningitis among Children with Febrile Seizure after the Pentavalent Vaccination
title_fullStr Change in Prevalence of Meningitis among Children with Febrile Seizure after the Pentavalent Vaccination
title_full_unstemmed Change in Prevalence of Meningitis among Children with Febrile Seizure after the Pentavalent Vaccination
title_short Change in Prevalence of Meningitis among Children with Febrile Seizure after the Pentavalent Vaccination
title_sort change in prevalence of meningitis among children with febrile seizure after the pentavalent vaccination
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10655218/
https://www.ncbi.nlm.nih.gov/pubmed/37981976
http://dx.doi.org/10.33696/neurol.4.079
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