WGX50 mitigates doxorubicin-induced cardiotoxicity through inhibition of mitochondrial ROS and ferroptosis

BACKGROUND: Doxorubicin (DOX)-induced cardiotoxicity (DIC) is a major impediment to its clinical application. It is indispensable to explore alternative treatment molecules or drugs for mitigating DIC. WGX50, an organic extract derived from Zanthoxylum bungeanum Maxim, has anti-inflammatory and anti...

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Detalles Bibliográficos
Autores principales: Tai, Panpan, Chen, Xinyu, Jia, Guihua, Chen, Guanjun, Gong, Lian, Cheng, Yaxin, Li, Zhuan, Wang, Heng, Chen, Aiyan, Zhang, Ganghua, Zhu, Yuxing, Xiao, Mengqing, Wang, Zhanwang, Liu, Yunqing, Shan, Dongyong, He, Dong, Li, Moying, Zhan, Tianzuo, Khan, Abbas, Li, Xiaohui, Zeng, Xiangxiang, Li, Chaopeng, Ouyang, Dongsheng, Ai, Kelong, Chen, Xuan, Liu, Dongbo, Liu, Zhonghua, Wei, Dongqing, Cao, Ke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10655295/
https://www.ncbi.nlm.nih.gov/pubmed/37978379
http://dx.doi.org/10.1186/s12967-023-04715-1

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