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Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons

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BACKGROUND: Progranulin (PGRN) is a lysosomal glycoprotein implicated in various neurodegenerative diseases, including frontotemporal dementia and neuronal ceroid lipofuscinosis. Over 70 mutations discovered in the GRN gene all result in reduced expression of the PGRN protein. Genetic and functional...

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Detalles Bibliográficos
Autores principales:	Hasan, Saadia, Fernandopulle, Michael S., Humble, Stewart W., Frankenfield, Ashley M., Li, Haorong, Prestil, Ryan, Johnson, Kory R., Ryan, Brent J., Wade-Martins, Richard, Ward, Michael E., Hao, Ling
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10655356/ https://www.ncbi.nlm.nih.gov/pubmed/37974165 http://dx.doi.org/10.1186/s13024-023-00673-w

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