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Diurnal differences in urine flow in healthy young men in a light-controlled environment: a randomized crossover design
BACKGROUND: Older men often experience nocturnal urination difficulties, reflected by diurnal differences in maximum urine flow (Qmax). Since lower urinary tract symptoms and pathological comorbidities are frequent in older men, it remains unclear whether this diurnal variation is a physiological or...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10655426/ https://www.ncbi.nlm.nih.gov/pubmed/37978565 http://dx.doi.org/10.1186/s40101-023-00346-z |
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author | Negoro, Hiromitsu Nakamoto, Isuzu Uiji, Sayaka Matsushima, Yoshiko Mathis, Bryan J. Kanikowska, Dominika Wakamura, Tomoko |
author_facet | Negoro, Hiromitsu Nakamoto, Isuzu Uiji, Sayaka Matsushima, Yoshiko Mathis, Bryan J. Kanikowska, Dominika Wakamura, Tomoko |
author_sort | Negoro, Hiromitsu |
collection | PubMed |
description | BACKGROUND: Older men often experience nocturnal urination difficulties, reflected by diurnal differences in maximum urine flow (Qmax). Since lower urinary tract symptoms and pathological comorbidities are frequent in older men, it remains unclear whether this diurnal variation is a physiological or pathological phenomenon. Our aim was to quantify the diurnal variability of Qmax in healthy young participants under varying daylight conditions in a stable environment to discern potential underlying causes of nocturnal urination difficulties. METHODS: Twenty-one healthy young men were recruited in a 4-day study utilizing daytime (08:00–18:00) exposure with two light conditions in randomized order: dim (< 50 lx) or bright (~2500 lx). Day 1 was for acclimation, and urine flow was assessed from day 2. The participants urinated ad libitum during day 2 and then at fixed 3–4-h intervals thereafter (days 3–4). Regular urination Qmax at late night (04:00) on day 4 was compared with the nearest voided volume during daytime of day 3 (mDay). RESULTS: Morning Qmax scores (after bed—11:00) on day 2 were significantly lower than evening (17:00—before pre-sleep) in bright conditions and those of daytime (11:00–17:00), evening (17:00—before pre-sleep), and pre-sleep in dim conditions. Pre-sleep Qmax during the ad libitum period was significantly higher in dim than bright conditions. Late-night Qmax values (04:00) on day 4 were significantly lower than Qmax scores of mDay on day 3 in both light conditions. CONCLUSIONS: Healthy young men had a clear diurnal Qmax difference that decreased during late night and morning. In addition, the pre-sleep Qmax values in dim daylight were significantly higher than in bright daylight. Taken together, we conclude that late-night and morning decreases in Qmax are an instinctive physiological phenomenon in humans, and the diurnal difference of Qmax can be influenced by daylight conditions. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40101-023-00346-z. |
format | Online Article Text |
id | pubmed-10655426 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-106554262023-11-17 Diurnal differences in urine flow in healthy young men in a light-controlled environment: a randomized crossover design Negoro, Hiromitsu Nakamoto, Isuzu Uiji, Sayaka Matsushima, Yoshiko Mathis, Bryan J. Kanikowska, Dominika Wakamura, Tomoko J Physiol Anthropol Original Article BACKGROUND: Older men often experience nocturnal urination difficulties, reflected by diurnal differences in maximum urine flow (Qmax). Since lower urinary tract symptoms and pathological comorbidities are frequent in older men, it remains unclear whether this diurnal variation is a physiological or pathological phenomenon. Our aim was to quantify the diurnal variability of Qmax in healthy young participants under varying daylight conditions in a stable environment to discern potential underlying causes of nocturnal urination difficulties. METHODS: Twenty-one healthy young men were recruited in a 4-day study utilizing daytime (08:00–18:00) exposure with two light conditions in randomized order: dim (< 50 lx) or bright (~2500 lx). Day 1 was for acclimation, and urine flow was assessed from day 2. The participants urinated ad libitum during day 2 and then at fixed 3–4-h intervals thereafter (days 3–4). Regular urination Qmax at late night (04:00) on day 4 was compared with the nearest voided volume during daytime of day 3 (mDay). RESULTS: Morning Qmax scores (after bed—11:00) on day 2 were significantly lower than evening (17:00—before pre-sleep) in bright conditions and those of daytime (11:00–17:00), evening (17:00—before pre-sleep), and pre-sleep in dim conditions. Pre-sleep Qmax during the ad libitum period was significantly higher in dim than bright conditions. Late-night Qmax values (04:00) on day 4 were significantly lower than Qmax scores of mDay on day 3 in both light conditions. CONCLUSIONS: Healthy young men had a clear diurnal Qmax difference that decreased during late night and morning. In addition, the pre-sleep Qmax values in dim daylight were significantly higher than in bright daylight. Taken together, we conclude that late-night and morning decreases in Qmax are an instinctive physiological phenomenon in humans, and the diurnal difference of Qmax can be influenced by daylight conditions. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40101-023-00346-z. BioMed Central 2023-11-17 /pmc/articles/PMC10655426/ /pubmed/37978565 http://dx.doi.org/10.1186/s40101-023-00346-z Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Original Article Negoro, Hiromitsu Nakamoto, Isuzu Uiji, Sayaka Matsushima, Yoshiko Mathis, Bryan J. Kanikowska, Dominika Wakamura, Tomoko Diurnal differences in urine flow in healthy young men in a light-controlled environment: a randomized crossover design |
title | Diurnal differences in urine flow in healthy young men in a light-controlled environment: a randomized crossover design |
title_full | Diurnal differences in urine flow in healthy young men in a light-controlled environment: a randomized crossover design |
title_fullStr | Diurnal differences in urine flow in healthy young men in a light-controlled environment: a randomized crossover design |
title_full_unstemmed | Diurnal differences in urine flow in healthy young men in a light-controlled environment: a randomized crossover design |
title_short | Diurnal differences in urine flow in healthy young men in a light-controlled environment: a randomized crossover design |
title_sort | diurnal differences in urine flow in healthy young men in a light-controlled environment: a randomized crossover design |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10655426/ https://www.ncbi.nlm.nih.gov/pubmed/37978565 http://dx.doi.org/10.1186/s40101-023-00346-z |
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