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Predictive value of ellipsoid zone-related angle parameters in primary surgery of large macular hole: a case control study

BACKGROUND: To explore the predictive value of Ellipsoid Zone (EZ) -related angle parameters for the outcome of primary macular hole surgery. METHODS: This was a retrospective study. Patients diagnosed with large macular hole (MH) (minimum diameter > 500 μm) between 2018 and 2021 were enrolled. A...

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Autores principales: Xia, Huaqin, Yang, Jiarui, Ding, Yi, Wang, Xinglin, Liao, Yanfeng, Shi, Yiwen, Dou, Hongliang, Li, Xuemin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10655441/
https://www.ncbi.nlm.nih.gov/pubmed/37978355
http://dx.doi.org/10.1186/s12886-023-03187-7
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author Xia, Huaqin
Yang, Jiarui
Ding, Yi
Wang, Xinglin
Liao, Yanfeng
Shi, Yiwen
Dou, Hongliang
Li, Xuemin
author_facet Xia, Huaqin
Yang, Jiarui
Ding, Yi
Wang, Xinglin
Liao, Yanfeng
Shi, Yiwen
Dou, Hongliang
Li, Xuemin
author_sort Xia, Huaqin
collection PubMed
description BACKGROUND: To explore the predictive value of Ellipsoid Zone (EZ) -related angle parameters for the outcome of primary macular hole surgery. METHODS: This was a retrospective study. Patients diagnosed with large macular hole (MH) (minimum diameter > 500 μm) between 2018 and 2021 were enrolled. All patients underwent 25-gauge pars plana vitrectomy, internal limiting membrane (ILM) peeling and air tamponade. Spectral-domain OCT (SD-OCT) and best corrected visual acuity (BCVA) were measured in preoperative and 2-week post-operative. Classic and angle related parameters were measured via ImageJ. Angle regularity (AR) were defined as the standard deviation of the angle parameters in vertical and horizontal direction. RESULTS: Seventy-six eyes were included for analysis; 24 eyes showed an unclosed macular hole at the 2-week postoperative and 52 eyes showed a closed hole. Preoperatively, MLD (P < 0.001), BD (P = 0.009) and diameter of EZ/ELM disruption (P = 0.002 and 0.025) in patients failed to close the hole after primary surgery were significantly larger than those succeeded. EZ-MH (P = 0.018), EZ-NFL (P = 0.006), EZ-GCL (P = 0.004), EZ-INL (P = 0.002), EZ-OPL (P = 0.009) and EZ-ONL (P = 0.011) angles were smaller in patients with unclosed hole. AR of the EZ-NFL (P = 0.009), EZ-GCL (P = 0.009), EZ-OPL (P = 0.023), EZ-ONL (P = 0.048) and Basal-NFL (P = 0.030) angles among the unclosed patients were significantly larger than those of the closed group. EZ-NFL (P = 0.015), EZ-GCL (P = 0.004), EZ-INL (P < 0.001), EZ-OPL (P < 0.001), EZ-ONL (P < 0.001), Basal (P = 0.023) and Basal-NFL (P < 0.001) angles of hole-unclosed patients enlarged significantly after the surgery. CONCLUSIONS: Patients with large macular holes and an increased EZ-related angle and angle AR are more likely to experience unsuccessful outcomes following primary MH surgery. Therefore, EZ-related angles hold potential as valuable parameters for predicting the surgical outcome. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12886-023-03187-7.
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spelling pubmed-106554412023-11-17 Predictive value of ellipsoid zone-related angle parameters in primary surgery of large macular hole: a case control study Xia, Huaqin Yang, Jiarui Ding, Yi Wang, Xinglin Liao, Yanfeng Shi, Yiwen Dou, Hongliang Li, Xuemin BMC Ophthalmol Research BACKGROUND: To explore the predictive value of Ellipsoid Zone (EZ) -related angle parameters for the outcome of primary macular hole surgery. METHODS: This was a retrospective study. Patients diagnosed with large macular hole (MH) (minimum diameter > 500 μm) between 2018 and 2021 were enrolled. All patients underwent 25-gauge pars plana vitrectomy, internal limiting membrane (ILM) peeling and air tamponade. Spectral-domain OCT (SD-OCT) and best corrected visual acuity (BCVA) were measured in preoperative and 2-week post-operative. Classic and angle related parameters were measured via ImageJ. Angle regularity (AR) were defined as the standard deviation of the angle parameters in vertical and horizontal direction. RESULTS: Seventy-six eyes were included for analysis; 24 eyes showed an unclosed macular hole at the 2-week postoperative and 52 eyes showed a closed hole. Preoperatively, MLD (P < 0.001), BD (P = 0.009) and diameter of EZ/ELM disruption (P = 0.002 and 0.025) in patients failed to close the hole after primary surgery were significantly larger than those succeeded. EZ-MH (P = 0.018), EZ-NFL (P = 0.006), EZ-GCL (P = 0.004), EZ-INL (P = 0.002), EZ-OPL (P = 0.009) and EZ-ONL (P = 0.011) angles were smaller in patients with unclosed hole. AR of the EZ-NFL (P = 0.009), EZ-GCL (P = 0.009), EZ-OPL (P = 0.023), EZ-ONL (P = 0.048) and Basal-NFL (P = 0.030) angles among the unclosed patients were significantly larger than those of the closed group. EZ-NFL (P = 0.015), EZ-GCL (P = 0.004), EZ-INL (P < 0.001), EZ-OPL (P < 0.001), EZ-ONL (P < 0.001), Basal (P = 0.023) and Basal-NFL (P < 0.001) angles of hole-unclosed patients enlarged significantly after the surgery. CONCLUSIONS: Patients with large macular holes and an increased EZ-related angle and angle AR are more likely to experience unsuccessful outcomes following primary MH surgery. Therefore, EZ-related angles hold potential as valuable parameters for predicting the surgical outcome. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12886-023-03187-7. BioMed Central 2023-11-17 /pmc/articles/PMC10655441/ /pubmed/37978355 http://dx.doi.org/10.1186/s12886-023-03187-7 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Xia, Huaqin
Yang, Jiarui
Ding, Yi
Wang, Xinglin
Liao, Yanfeng
Shi, Yiwen
Dou, Hongliang
Li, Xuemin
Predictive value of ellipsoid zone-related angle parameters in primary surgery of large macular hole: a case control study
title Predictive value of ellipsoid zone-related angle parameters in primary surgery of large macular hole: a case control study
title_full Predictive value of ellipsoid zone-related angle parameters in primary surgery of large macular hole: a case control study
title_fullStr Predictive value of ellipsoid zone-related angle parameters in primary surgery of large macular hole: a case control study
title_full_unstemmed Predictive value of ellipsoid zone-related angle parameters in primary surgery of large macular hole: a case control study
title_short Predictive value of ellipsoid zone-related angle parameters in primary surgery of large macular hole: a case control study
title_sort predictive value of ellipsoid zone-related angle parameters in primary surgery of large macular hole: a case control study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10655441/
https://www.ncbi.nlm.nih.gov/pubmed/37978355
http://dx.doi.org/10.1186/s12886-023-03187-7
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