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Identification of a novel COL7A1 variant associated with dystrophic epidermolysis bullosa pruriginosa responding effectively to dupilumab

BACKGROUND: Variants in COL7A1 cause an extremely rare and clinically heterogeneous syndrome known as dystrophic epidermolysis bullosa pruriginosa (DEB‐Pr). Duplilumab, a fully humanized anti‐IL‐4Ra monoclonal antibody, can inhibit IL‐4 and IL‐13‐driven signaling. METHODS: Ethical Compliance: Follow...

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Detalles Bibliográficos
Autores principales:	Zhao, Caichou, Cao, Shuanglin, Gao, Xinghua, Xu, Xuegang, Gu, Lixiong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10655508/ https://www.ncbi.nlm.nih.gov/pubmed/37676173 http://dx.doi.org/10.1002/mgg3.2258

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