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Serum DHEA and Testosterone Levels Associate Inversely With Coronary Artery Calcification in Elderly Men

CONTEXT: Epidemiological and preclinical data support cardiovascular, mainly protective, effects of sex steroids in men, but the mechanisms underlying the cardiovascular actions of sex steroids are poorly understood. Vascular calcification parallels the development of atherosclerosis, but is increas...

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Autores principales: Ohlsson, Claes, Nethander, Maria, Norlén, Anna-Karin, Poutanen, Matti, Gudmundsson, Elias Freyr, Aspelund, Thor, Sigurdsson, Sigurdur, Ryberg, Henrik, Gudnason, Vilmundur, Tivesten, Åsa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10655543/
https://www.ncbi.nlm.nih.gov/pubmed/37391895
http://dx.doi.org/10.1210/clinem/dgad351
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author Ohlsson, Claes
Nethander, Maria
Norlén, Anna-Karin
Poutanen, Matti
Gudmundsson, Elias Freyr
Aspelund, Thor
Sigurdsson, Sigurdur
Ryberg, Henrik
Gudnason, Vilmundur
Tivesten, Åsa
author_facet Ohlsson, Claes
Nethander, Maria
Norlén, Anna-Karin
Poutanen, Matti
Gudmundsson, Elias Freyr
Aspelund, Thor
Sigurdsson, Sigurdur
Ryberg, Henrik
Gudnason, Vilmundur
Tivesten, Åsa
author_sort Ohlsson, Claes
collection PubMed
description CONTEXT: Epidemiological and preclinical data support cardiovascular, mainly protective, effects of sex steroids in men, but the mechanisms underlying the cardiovascular actions of sex steroids are poorly understood. Vascular calcification parallels the development of atherosclerosis, but is increasingly recognized as a diversified, highly regulated process, which itself may have pathophysiological importance for clinical cardiovascular events. OBJECTIVE: To investigate the association between serum sex steroids and coronary artery calcification (CAC) in elderly men. METHODS: We used gas chromatography tandem mass spectrometry to analyze a comprehensive sex steroid profile, including levels of dehydroepiandrosterone (DHEA), androstenedione, estrone, testosterone, estradiol, and dihydrotestosterone, in men from the population-based AGES-Reykjavik study (n = 1287, mean 76 years). Further, sex hormone–binding globulin (SHBG) was assayed and bioavailable hormone levels calculated. CAC score was determined by computed tomography. The main outcome measures were cross-sectional associations between dehydroepiandrosterone, androstenedione, estrone, testosterone, dihydrotestosterone, and estradiol and quintiles of CAC. RESULTS: Serum levels of DHEA, androstenedione, testosterone, dihydrotestosterone, and bioavailable testosterone showed significant inverse associations with CAC, while estrone, estradiol, bioavailable estradiol, and SHBG did not. DHEA, testosterone, and bioavailable testosterone remained associated with CAC after adjustment for traditional cardiovascular risk factors. In addition, our results support partially independent associations between adrenal-derived DHEA and testes-derived testosterone and CAC. CONCLUSION: Serum levels of DHEA and testosterone are inversely associated with CAC in elderly men, partially independently from each other. These results raise the question whether androgens from both the adrenals and the testes may contribute to male cardiovascular health.
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spelling pubmed-106555432023-06-12 Serum DHEA and Testosterone Levels Associate Inversely With Coronary Artery Calcification in Elderly Men Ohlsson, Claes Nethander, Maria Norlén, Anna-Karin Poutanen, Matti Gudmundsson, Elias Freyr Aspelund, Thor Sigurdsson, Sigurdur Ryberg, Henrik Gudnason, Vilmundur Tivesten, Åsa J Clin Endocrinol Metab Clinical Research Article CONTEXT: Epidemiological and preclinical data support cardiovascular, mainly protective, effects of sex steroids in men, but the mechanisms underlying the cardiovascular actions of sex steroids are poorly understood. Vascular calcification parallels the development of atherosclerosis, but is increasingly recognized as a diversified, highly regulated process, which itself may have pathophysiological importance for clinical cardiovascular events. OBJECTIVE: To investigate the association between serum sex steroids and coronary artery calcification (CAC) in elderly men. METHODS: We used gas chromatography tandem mass spectrometry to analyze a comprehensive sex steroid profile, including levels of dehydroepiandrosterone (DHEA), androstenedione, estrone, testosterone, estradiol, and dihydrotestosterone, in men from the population-based AGES-Reykjavik study (n = 1287, mean 76 years). Further, sex hormone–binding globulin (SHBG) was assayed and bioavailable hormone levels calculated. CAC score was determined by computed tomography. The main outcome measures were cross-sectional associations between dehydroepiandrosterone, androstenedione, estrone, testosterone, dihydrotestosterone, and estradiol and quintiles of CAC. RESULTS: Serum levels of DHEA, androstenedione, testosterone, dihydrotestosterone, and bioavailable testosterone showed significant inverse associations with CAC, while estrone, estradiol, bioavailable estradiol, and SHBG did not. DHEA, testosterone, and bioavailable testosterone remained associated with CAC after adjustment for traditional cardiovascular risk factors. In addition, our results support partially independent associations between adrenal-derived DHEA and testes-derived testosterone and CAC. CONCLUSION: Serum levels of DHEA and testosterone are inversely associated with CAC in elderly men, partially independently from each other. These results raise the question whether androgens from both the adrenals and the testes may contribute to male cardiovascular health. Oxford University Press 2023-06-12 /pmc/articles/PMC10655543/ /pubmed/37391895 http://dx.doi.org/10.1210/clinem/dgad351 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of the Endocrine Society. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Clinical Research Article
Ohlsson, Claes
Nethander, Maria
Norlén, Anna-Karin
Poutanen, Matti
Gudmundsson, Elias Freyr
Aspelund, Thor
Sigurdsson, Sigurdur
Ryberg, Henrik
Gudnason, Vilmundur
Tivesten, Åsa
Serum DHEA and Testosterone Levels Associate Inversely With Coronary Artery Calcification in Elderly Men
title Serum DHEA and Testosterone Levels Associate Inversely With Coronary Artery Calcification in Elderly Men
title_full Serum DHEA and Testosterone Levels Associate Inversely With Coronary Artery Calcification in Elderly Men
title_fullStr Serum DHEA and Testosterone Levels Associate Inversely With Coronary Artery Calcification in Elderly Men
title_full_unstemmed Serum DHEA and Testosterone Levels Associate Inversely With Coronary Artery Calcification in Elderly Men
title_short Serum DHEA and Testosterone Levels Associate Inversely With Coronary Artery Calcification in Elderly Men
title_sort serum dhea and testosterone levels associate inversely with coronary artery calcification in elderly men
topic Clinical Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10655543/
https://www.ncbi.nlm.nih.gov/pubmed/37391895
http://dx.doi.org/10.1210/clinem/dgad351
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