KMT2A maintains stemness of gastric cancer cells through regulating Wnt/β-catenin signaling-activated transcriptional factor KLF11

The molecular mechanisms of epigenetic regulation in gastric cancer development are not yet well established. In this study, we demonstrated that KMT2A was highly expressed in gastric cancer and associated with poor outcomes of patients and revealed that KMT2A was significantly associated with stemn...

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Autores principales: Deng, Chongwen, Ye, Chunhua, Liao, Xiwang, Zhou, Fuyin, Shi, Youxiong, Zhong, Hong, Huang, Junbiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: De Gruyter 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10655684/
https://www.ncbi.nlm.nih.gov/pubmed/38025523
http://dx.doi.org/10.1515/med-2023-0764
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author Deng, Chongwen
Ye, Chunhua
Liao, Xiwang
Zhou, Fuyin
Shi, Youxiong
Zhong, Hong
Huang, Junbiao
author_facet Deng, Chongwen
Ye, Chunhua
Liao, Xiwang
Zhou, Fuyin
Shi, Youxiong
Zhong, Hong
Huang, Junbiao
author_sort Deng, Chongwen
collection PubMed
description The molecular mechanisms of epigenetic regulation in gastric cancer development are not yet well established. In this study, we demonstrated that KMT2A was highly expressed in gastric cancer and associated with poor outcomes of patients and revealed that KMT2A was significantly associated with stemness and increased nuclear β-catenin in gastric cancer. Mechanistically, KMT2A activated the translocation of β-catenin into the nucleus of gastric cancer cells, and then, β-catenin served as a coactivator of KLF11, which promoted the expression of specific gastric cancer stemness-related molecules, including SOX2 and FOXM1. Together, KMT2A is an important epigenetic regulator of gastric cancer stemness, which provides a novel insight to the potential application of targeting against KMT2A in treating gastric cancer.
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spelling pubmed-106556842023-11-07 KMT2A maintains stemness of gastric cancer cells through regulating Wnt/β-catenin signaling-activated transcriptional factor KLF11 Deng, Chongwen Ye, Chunhua Liao, Xiwang Zhou, Fuyin Shi, Youxiong Zhong, Hong Huang, Junbiao Open Med (Wars) Research Article The molecular mechanisms of epigenetic regulation in gastric cancer development are not yet well established. In this study, we demonstrated that KMT2A was highly expressed in gastric cancer and associated with poor outcomes of patients and revealed that KMT2A was significantly associated with stemness and increased nuclear β-catenin in gastric cancer. Mechanistically, KMT2A activated the translocation of β-catenin into the nucleus of gastric cancer cells, and then, β-catenin served as a coactivator of KLF11, which promoted the expression of specific gastric cancer stemness-related molecules, including SOX2 and FOXM1. Together, KMT2A is an important epigenetic regulator of gastric cancer stemness, which provides a novel insight to the potential application of targeting against KMT2A in treating gastric cancer. De Gruyter 2023-11-07 /pmc/articles/PMC10655684/ /pubmed/38025523 http://dx.doi.org/10.1515/med-2023-0764 Text en © 2023 the author(s), published by De Gruyter https://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 International License.
spellingShingle Research Article
Deng, Chongwen
Ye, Chunhua
Liao, Xiwang
Zhou, Fuyin
Shi, Youxiong
Zhong, Hong
Huang, Junbiao
KMT2A maintains stemness of gastric cancer cells through regulating Wnt/β-catenin signaling-activated transcriptional factor KLF11
title KMT2A maintains stemness of gastric cancer cells through regulating Wnt/β-catenin signaling-activated transcriptional factor KLF11
title_full KMT2A maintains stemness of gastric cancer cells through regulating Wnt/β-catenin signaling-activated transcriptional factor KLF11
title_fullStr KMT2A maintains stemness of gastric cancer cells through regulating Wnt/β-catenin signaling-activated transcriptional factor KLF11
title_full_unstemmed KMT2A maintains stemness of gastric cancer cells through regulating Wnt/β-catenin signaling-activated transcriptional factor KLF11
title_short KMT2A maintains stemness of gastric cancer cells through regulating Wnt/β-catenin signaling-activated transcriptional factor KLF11
title_sort kmt2a maintains stemness of gastric cancer cells through regulating wnt/β-catenin signaling-activated transcriptional factor klf11
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10655684/
https://www.ncbi.nlm.nih.gov/pubmed/38025523
http://dx.doi.org/10.1515/med-2023-0764
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