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Characteristic of persistent human papillomavirus infection in women worldwide: a meta–analysis
OBJECTIVES: We aimed to estimate the genotype distribution of persistent human papillomavirus (HPV) infection in females worldwide, and provided a scientific basis for the prevention strategies of cervical cancer (CC) and the development of HPV vaccines. METHODS: Both English and Chinese databases w...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
PeerJ Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10655709/ https://www.ncbi.nlm.nih.gov/pubmed/38025679 http://dx.doi.org/10.7717/peerj.16247 |
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author | Zhao, Ming Zhou, Dan Zhang, Min Kang, Peipei Cui, Meimei Zhu, Liling Luo, Limei |
author_facet | Zhao, Ming Zhou, Dan Zhang, Min Kang, Peipei Cui, Meimei Zhu, Liling Luo, Limei |
author_sort | Zhao, Ming |
collection | PubMed |
description | OBJECTIVES: We aimed to estimate the genotype distribution of persistent human papillomavirus (HPV) infection in females worldwide, and provided a scientific basis for the prevention strategies of cervical cancer (CC) and the development of HPV vaccines. METHODS: Both English and Chinese databases were researched from the inception to July 2023. The pooled persistent HPV infection prevalence was calculated using a random effects model. The subgroup analysis was performed to explore the heterogeneity. Publication bias was evaluated using funnel plot, Egger’s and Begg’s test. RESULTS: Twenty-eight studies with 27,335 participants were included. The pooled prevalence of persistent HPV infection was 29.37% (95% CI [24.05%∼35.31%]), and the genotypes with the persistent infection prevalence were HPV16 (35.01%), HPV52 (28.19%), HPV58 (27.06%), HPV18 (25.99%), HPV33 (24.37%), HPV31 (23.35%), HPV59 (21.87%), HPV39 (19.54%), HPV68 (16.61%) and HPV45 (15.05%). The prevalence of multiple and single HPV persistent infection were 48.66% and 36.71%, respectively; the prevalence of persistent HPV infection in different age groups (<30, 30∼39, 40∼49, >50) were 29.83%, 28.39%, 22.24% and 30.22%, respectively. The follow-up time was significantly associated with heterogeneity by subgroup analysis (P < 0.05), and the prevalence of persistent infection decreased with longer follow-up time. CONCLUSIONS: Multiple infections were more likely to occur persistent HPV infection than single infection. In addition to HPV vaccination, we should emphasize the follow-up management for women under 30 and over 50 years old, those with high-risk HPV infection (HPV59, 39, 68) and multiple infections. |
format | Online Article Text |
id | pubmed-10655709 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | PeerJ Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-106557092023-11-14 Characteristic of persistent human papillomavirus infection in women worldwide: a meta–analysis Zhao, Ming Zhou, Dan Zhang, Min Kang, Peipei Cui, Meimei Zhu, Liling Luo, Limei PeerJ Virology OBJECTIVES: We aimed to estimate the genotype distribution of persistent human papillomavirus (HPV) infection in females worldwide, and provided a scientific basis for the prevention strategies of cervical cancer (CC) and the development of HPV vaccines. METHODS: Both English and Chinese databases were researched from the inception to July 2023. The pooled persistent HPV infection prevalence was calculated using a random effects model. The subgroup analysis was performed to explore the heterogeneity. Publication bias was evaluated using funnel plot, Egger’s and Begg’s test. RESULTS: Twenty-eight studies with 27,335 participants were included. The pooled prevalence of persistent HPV infection was 29.37% (95% CI [24.05%∼35.31%]), and the genotypes with the persistent infection prevalence were HPV16 (35.01%), HPV52 (28.19%), HPV58 (27.06%), HPV18 (25.99%), HPV33 (24.37%), HPV31 (23.35%), HPV59 (21.87%), HPV39 (19.54%), HPV68 (16.61%) and HPV45 (15.05%). The prevalence of multiple and single HPV persistent infection were 48.66% and 36.71%, respectively; the prevalence of persistent HPV infection in different age groups (<30, 30∼39, 40∼49, >50) were 29.83%, 28.39%, 22.24% and 30.22%, respectively. The follow-up time was significantly associated with heterogeneity by subgroup analysis (P < 0.05), and the prevalence of persistent infection decreased with longer follow-up time. CONCLUSIONS: Multiple infections were more likely to occur persistent HPV infection than single infection. In addition to HPV vaccination, we should emphasize the follow-up management for women under 30 and over 50 years old, those with high-risk HPV infection (HPV59, 39, 68) and multiple infections. PeerJ Inc. 2023-11-14 /pmc/articles/PMC10655709/ /pubmed/38025679 http://dx.doi.org/10.7717/peerj.16247 Text en ©2023 Zhao et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited. |
spellingShingle | Virology Zhao, Ming Zhou, Dan Zhang, Min Kang, Peipei Cui, Meimei Zhu, Liling Luo, Limei Characteristic of persistent human papillomavirus infection in women worldwide: a meta–analysis |
title | Characteristic of persistent human papillomavirus infection in women worldwide: a meta–analysis |
title_full | Characteristic of persistent human papillomavirus infection in women worldwide: a meta–analysis |
title_fullStr | Characteristic of persistent human papillomavirus infection in women worldwide: a meta–analysis |
title_full_unstemmed | Characteristic of persistent human papillomavirus infection in women worldwide: a meta–analysis |
title_short | Characteristic of persistent human papillomavirus infection in women worldwide: a meta–analysis |
title_sort | characteristic of persistent human papillomavirus infection in women worldwide: a meta–analysis |
topic | Virology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10655709/ https://www.ncbi.nlm.nih.gov/pubmed/38025679 http://dx.doi.org/10.7717/peerj.16247 |
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