DUX4 expression activates JNK and p38 MAP kinases in myoblasts

Facioscapulohumeral muscular dystrophy (FSHD) is caused by misexpression of the DUX4 transcription factor in skeletal muscle that results in transcriptional alterations, abnormal phenotypes and cell death. To gain insight into the kinetics of DUX4-induced stresses, we activated DUX4 expression in my...

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Detalles Bibliográficos
Autores principales: Brennan, Christopher M., Hill, Abby S., St. Andre, Michael, Li, Xianfeng, Madeti, Vijaya, Breitkopf, Susanne, Garren, Seth, Xue, Liang, Gilbert, Tamara, Hadjipanayis, Angela, Monetti, Mara, Emerson, Charles P., Moccia, Robert, Owens, Jane, Christoforou, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10655719/
https://www.ncbi.nlm.nih.gov/pubmed/36196640
http://dx.doi.org/10.1242/dmm.049516

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