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Cross-Sectional Relationship Between Atrial Conduction Delay and Arterial Stiffness in Patients with Obstructive Sleep Apnea

AIM: Prolonged P-wave duration (PWD), which indicates atrial conduction delay, is a potent precursor of atrial fibrillation (AF) that may be induced by obstructive sleep apnea (OSA). The cardio-ankle vascular index (CAVI), which is an arterial stiffness parameter, is elevated in patients with OSA; m...

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Autores principales: Ueda, Azusa, Kasagi, Satoshi, Maeno, Ken-ichi, Naito, Ryo, Kumagai, Takiko, Kimura, Yuka, Kato, Mitsue, Kawana, Fusae, Tomita, Yasuhiro, Narui, Koji, Kasai, Takatoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10655741/
https://www.ncbi.nlm.nih.gov/pubmed/38025517
http://dx.doi.org/10.2147/VHRM.S428713
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author Ueda, Azusa
Kasagi, Satoshi
Maeno, Ken-ichi
Naito, Ryo
Kumagai, Takiko
Kimura, Yuka
Kato, Mitsue
Kawana, Fusae
Tomita, Yasuhiro
Narui, Koji
Kasai, Takatoshi
author_facet Ueda, Azusa
Kasagi, Satoshi
Maeno, Ken-ichi
Naito, Ryo
Kumagai, Takiko
Kimura, Yuka
Kato, Mitsue
Kawana, Fusae
Tomita, Yasuhiro
Narui, Koji
Kasai, Takatoshi
author_sort Ueda, Azusa
collection PubMed
description AIM: Prolonged P-wave duration (PWD), which indicates atrial conduction delay, is a potent precursor of atrial fibrillation (AF) that may be induced by obstructive sleep apnea (OSA). The cardio-ankle vascular index (CAVI), which is an arterial stiffness parameter, is elevated in patients with OSA; moreover, an increased CAVI is associated with atrial conduction delay through left atrium enlargement in association with left ventricular diastolic dysfunction. We aimed to examine the relationship between the CAVI and PWD in patients with OSA. METHODS: We included patients with a sinus rhythm who underwent overnight polysomnography. We measured the PWD and CAVI on standard 12-lead electrocardiograms; further, we analyzed the relationship between PWD and CAVI. RESULTS: We analyzed data from 300 participants (men, 89.0%; mean age, 52.3 ± 13.1 years; and body mass index, 26.2 ± 3.9 kg/m(2)). The mean PWD was 104.4 ± 10.4 ms while the mean CAVI was 7.5 ± 1.5. PWD was significantly correlated with CAVI (r = 0.478, p < 0.001); additionally, PWD and CAVI were directly associated with OSA severity (p = 0.002 and p = 0.002, respectively). Multivariate regression analysis revealed an independent significant correlation of PWD and CAVI with OSA severity. CONCLUSION: In patients with OSA, an increase in arterial stiffness is associated with atrial conduction delay.
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spelling pubmed-106557412023-11-13 Cross-Sectional Relationship Between Atrial Conduction Delay and Arterial Stiffness in Patients with Obstructive Sleep Apnea Ueda, Azusa Kasagi, Satoshi Maeno, Ken-ichi Naito, Ryo Kumagai, Takiko Kimura, Yuka Kato, Mitsue Kawana, Fusae Tomita, Yasuhiro Narui, Koji Kasai, Takatoshi Vasc Health Risk Manag Original Research AIM: Prolonged P-wave duration (PWD), which indicates atrial conduction delay, is a potent precursor of atrial fibrillation (AF) that may be induced by obstructive sleep apnea (OSA). The cardio-ankle vascular index (CAVI), which is an arterial stiffness parameter, is elevated in patients with OSA; moreover, an increased CAVI is associated with atrial conduction delay through left atrium enlargement in association with left ventricular diastolic dysfunction. We aimed to examine the relationship between the CAVI and PWD in patients with OSA. METHODS: We included patients with a sinus rhythm who underwent overnight polysomnography. We measured the PWD and CAVI on standard 12-lead electrocardiograms; further, we analyzed the relationship between PWD and CAVI. RESULTS: We analyzed data from 300 participants (men, 89.0%; mean age, 52.3 ± 13.1 years; and body mass index, 26.2 ± 3.9 kg/m(2)). The mean PWD was 104.4 ± 10.4 ms while the mean CAVI was 7.5 ± 1.5. PWD was significantly correlated with CAVI (r = 0.478, p < 0.001); additionally, PWD and CAVI were directly associated with OSA severity (p = 0.002 and p = 0.002, respectively). Multivariate regression analysis revealed an independent significant correlation of PWD and CAVI with OSA severity. CONCLUSION: In patients with OSA, an increase in arterial stiffness is associated with atrial conduction delay. Dove 2023-11-13 /pmc/articles/PMC10655741/ /pubmed/38025517 http://dx.doi.org/10.2147/VHRM.S428713 Text en © 2023 Ueda et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Ueda, Azusa
Kasagi, Satoshi
Maeno, Ken-ichi
Naito, Ryo
Kumagai, Takiko
Kimura, Yuka
Kato, Mitsue
Kawana, Fusae
Tomita, Yasuhiro
Narui, Koji
Kasai, Takatoshi
Cross-Sectional Relationship Between Atrial Conduction Delay and Arterial Stiffness in Patients with Obstructive Sleep Apnea
title Cross-Sectional Relationship Between Atrial Conduction Delay and Arterial Stiffness in Patients with Obstructive Sleep Apnea
title_full Cross-Sectional Relationship Between Atrial Conduction Delay and Arterial Stiffness in Patients with Obstructive Sleep Apnea
title_fullStr Cross-Sectional Relationship Between Atrial Conduction Delay and Arterial Stiffness in Patients with Obstructive Sleep Apnea
title_full_unstemmed Cross-Sectional Relationship Between Atrial Conduction Delay and Arterial Stiffness in Patients with Obstructive Sleep Apnea
title_short Cross-Sectional Relationship Between Atrial Conduction Delay and Arterial Stiffness in Patients with Obstructive Sleep Apnea
title_sort cross-sectional relationship between atrial conduction delay and arterial stiffness in patients with obstructive sleep apnea
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10655741/
https://www.ncbi.nlm.nih.gov/pubmed/38025517
http://dx.doi.org/10.2147/VHRM.S428713
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