Cargando…

Bridging the Translational Gap in Heart Failure Research: Using Human iPSC-derived Cardiomyocytes to Accelerate Therapeutic Insights

Heart failure (HF) remains a leading cause of death worldwide, with increasing prevalence and burden. Despite extensive research, a cure for HF remains elusive. Traditionally, the study of HF’s pathogenesis and therapies has relied heavily on animal experimentation. However, these models have limita...

Descripción completa

Detalles Bibliográficos
Autores principales:	Venegas-Zamora, Leslye, Fiedler, Matthew, Perez, William, Altamirano, Francisco
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Houston Methodist DeBakey Heart & Vascular Center 2023
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10655754/ https://www.ncbi.nlm.nih.gov/pubmed/38028973 http://dx.doi.org/10.14797/mdcvj.1295

Ejemplares similares

Bridging the Translational Gap in Chemotherapy-Induced Peripheral Neuropathy with iPSC-Based Modeling
por: Mortensen, Christina, et al.
Publicado: (2022)

Maturing iPSC-Derived Cardiomyocytes
por: Tang, Bor Luen
Publicado: (2020)

The Utilisation of Hydrogels for iPSC-Cardiomyocyte Research
por: Patel, Leena, et al.
Publicado: (2023)

Unchain My Heart: Integrins at the Basis of iPSC Cardiomyocyte Differentiation
por: Santoro, Rosaria, et al.
Publicado: (2019)

Transplantation of purified iPSC-derived cardiomyocytes in myocardial infarction
por: Rojas, Sebastian V., et al.
Publicado: (2017)

Analysis of Drug Effects on iPSC Cardiomyocytes with Machine Learning
por: Juhola, Martti, et al.
Publicado: (2020)

The Structural and the Functional Aspects of Intercellular Communication in iPSC-Cardiomyocytes
por: Kiss, Eva, et al.
Publicado: (2022)

Dynamic alternative polyadenylation during iPSC differentiation into cardiomyocytes
por: Yang, Yanbo, et al.
Publicado: (2022)

Modelling sarcomeric cardiomyopathies in the dish: from human heart samples to iPSC cardiomyocytes
por: Eschenhagen, Thomas, et al.
Publicado: (2015)

The antineoplastic drug, trastuzumab, dysregulates metabolism in iPSC-derived cardiomyocytes
por: Necela, Brian M., et al.
Publicado: (2017)

Space microgravity improves proliferation of human iPSC-derived cardiomyocytes
por: Rampoldi, Antonio, et al.
Publicado: (2022)

Gene Modulation with CRISPR-based Tools in Human iPSC-Cardiomyocytes
por: Han, Julie Leann, et al.
Publicado: (2023)

A Comparative Assessment of Human and Chimpanzee iPSC-derived Cardiomyocytes with Primary Heart Tissues
por: Pavlovic, Bryan J., et al.
Publicado: (2018)

Serum of patients with acute myocardial infarction prevents inflammation in iPSC-cardiomyocytes
por: Sattler, Katherine, et al.
Publicado: (2019)

Rapid Assessment of Proarrhythmic Potential Using Human iPSC-Derived Cardiomyocytes
por: Geiger, Robert M., et al.
Publicado: (2020)

iPSC-Cardiomyocyte Models of Brugada Syndrome—Achievements, Challenges and Future Perspectives
por: Nijak, Aleksandra, et al.
Publicado: (2021)

Morpho-functional comparison of differentiation protocols to create iPSC-derived cardiomyocytes
por: Nijak, Aleksandra, et al.
Publicado: (2022)

Sarcomere Disassembly and Transfection Efficiency in Proliferating Human iPSC-Derived Cardiomyocytes
por: Yuan, Qianliang, et al.
Publicado: (2022)

Functional and molecular effects of TNF-α on human iPSC-derived cardiomyocytes
por: Saraf, Anita, et al.
Publicado: (2021)

Human iPSC-Cardiomyocytes as an Experimental Model to Study Epigenetic Modifiers of Electrophysiology
por: Pozo, Maria R., et al.
Publicado: (2022)

ACTN2 Mutant Causes Proteopathy in Human iPSC-Derived Cardiomyocytes
por: Zech, Antonia T. L., et al.
Publicado: (2022)

Co-culture with neonatal cardiomyocytes enhances the proliferation of iPSC-derived cardiomyocytes via FAK/JNK signaling
por: Ou, Dongbo, et al.
Publicado: (2016)

Enhanced engraftment, proliferation, and therapeutic potential in heart using optimized human iPSC-derived cardiomyocytes
por: Funakoshi, Shunsuke, et al.
Publicado: (2016)

New Insights into the Hepcidin-Ferroportin Axis and Iron Homeostasis in iPSC-Derived Cardiomyocytes from Friedreich's Ataxia Patient
por: Bolotta, Alessandra, et al.
Publicado: (2019)

Characterization of cytoskeleton features and maturation status of cultured human iPSC-derived cardiomyocytes
por: Zuppinger, Christian, et al.
Publicado: (2017)

Hydrojet-based delivery of footprint-free iPSC-derived cardiomyocytes into porcine myocardium
por: Weber, Marbod, et al.
Publicado: (2020)

Human iPSC-Derived Cardiomyocytes Are Susceptible to SARS-CoV-2 Infection
por: Sharma, Arun, et al.
Publicado: (2020)

Metabolic Maturation Media Improve Physiological Function of Human iPSC-Derived Cardiomyocytes
por: M. Feyen, Dries A., et al.
Publicado: (2020)

Effect of hydroxychloroquine on proarrhythmia risk assessment using human iPSC-derived cardiomyocytes
por: Yanagida, Shota, et al.
Publicado: (2021)

cAMP-PKA signaling modulates the automaticity of human iPSC-derived cardiomyocytes
por: Mazgaoker, Savyon, et al.
Publicado: (2022)

iPSC-Derived Cardiomyocytes in Inherited Cardiac Arrhythmias: Pathomechanistic Discovery and Drug Development
por: Simons, Eline, et al.
Publicado: (2023)

Mechanistic and Translational Advances Using iPSC-Derived Blood Cells
por: Thom, Christopher S, et al.
Publicado: (2020)

RNA Expression Profiling of Human iPSC-Derived Cardiomyocytes in a Cardiac Hypertrophy Model
por: Aggarwal, Praful, et al.
Publicado: (2014)

Electrophysiological Characteristics of Human iPSC-Derived Cardiomyocytes for the Assessment of Drug-Induced Proarrhythmic Potential
por: Yamamoto, Wataru, et al.
Publicado: (2016)

Stage-specific Effects of Bioactive Lipids on Human iPSC Cardiac Differentiation and Cardiomyocyte Proliferation
por: Sharma, Arun, et al.
Publicado: (2018)

Empagliflozin Ammeliorates High Glucose Induced-Cardiac Dysfuntion in Human iPSC-Derived Cardiomyocytes
por: Ng, Kwong-Man, et al.
Publicado: (2018)

Frequency-dependent drug screening using optogenetic stimulation of human iPSC-derived cardiomyocytes
por: Lapp, Hendrik, et al.
Publicado: (2017)

A generally conserved response to hypoxia in iPSC-derived cardiomyocytes from humans and chimpanzees
por: Ward, Michelle C, et al.
Publicado: (2019)

Assessment of temporal functional changes and miRNA profiling of human iPSC-derived cardiomyocytes
por: Kumar, Naresh, et al.
Publicado: (2019)

Syncytium cell growth increases Kir2.1 contribution in human iPSC-cardiomyocytes
por: Li, Weizhen, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_e5mg79bdm2n44g4k577tq1kgbs