Metabolic Control of Cardiomyocyte Cell Cycle

Current therapies for heart failure aim to prevent the deleterious remodeling that occurs after MI injury, but currently no therapies are available to replace lost cardiomyocytes. Several organisms now being studied are capable of regenerating their myocardium by the proliferation of existing cardio...

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Detalles Bibliográficos
Autores principales: Menendez-Montes, Ivan, Garry, Daniel J., Zhang, Jianyi (Jay), Sadek, Hesham A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Houston Methodist DeBakey Heart & Vascular Center 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10655756/
https://www.ncbi.nlm.nih.gov/pubmed/38028975
http://dx.doi.org/10.14797/mdcvj.1309
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author Menendez-Montes, Ivan
Garry, Daniel J.
Zhang, Jianyi (Jay)
Sadek, Hesham A.
author_facet Menendez-Montes, Ivan
Garry, Daniel J.
Zhang, Jianyi (Jay)
Sadek, Hesham A.
author_sort Menendez-Montes, Ivan
collection PubMed
description Current therapies for heart failure aim to prevent the deleterious remodeling that occurs after MI injury, but currently no therapies are available to replace lost cardiomyocytes. Several organisms now being studied are capable of regenerating their myocardium by the proliferation of existing cardiomyocytes. In this review, we summarize the main metabolic pathways of the mammalian heart and how modulation of these metabolic pathways through genetic and pharmacological approaches influences cardiomyocyte proliferation and heart regeneration.
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spelling pubmed-106557562023-11-16 Metabolic Control of Cardiomyocyte Cell Cycle Menendez-Montes, Ivan Garry, Daniel J. Zhang, Jianyi (Jay) Sadek, Hesham A. Methodist Debakey Cardiovasc J Review Current therapies for heart failure aim to prevent the deleterious remodeling that occurs after MI injury, but currently no therapies are available to replace lost cardiomyocytes. Several organisms now being studied are capable of regenerating their myocardium by the proliferation of existing cardiomyocytes. In this review, we summarize the main metabolic pathways of the mammalian heart and how modulation of these metabolic pathways through genetic and pharmacological approaches influences cardiomyocyte proliferation and heart regeneration. Houston Methodist DeBakey Heart & Vascular Center 2023-11-16 /pmc/articles/PMC10655756/ /pubmed/38028975 http://dx.doi.org/10.14797/mdcvj.1309 Text en Copyright: © 2023 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC-BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. See http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review
Menendez-Montes, Ivan
Garry, Daniel J.
Zhang, Jianyi (Jay)
Sadek, Hesham A.
Metabolic Control of Cardiomyocyte Cell Cycle
title Metabolic Control of Cardiomyocyte Cell Cycle
title_full Metabolic Control of Cardiomyocyte Cell Cycle
title_fullStr Metabolic Control of Cardiomyocyte Cell Cycle
title_full_unstemmed Metabolic Control of Cardiomyocyte Cell Cycle
title_short Metabolic Control of Cardiomyocyte Cell Cycle
title_sort metabolic control of cardiomyocyte cell cycle
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10655756/
https://www.ncbi.nlm.nih.gov/pubmed/38028975
http://dx.doi.org/10.14797/mdcvj.1309
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