SHIP1 therapeutic target enablement: Identification and evaluation of inhibitors for the treatment of late‐onset Alzheimer's disease

INTRODUCTION: The risk of developing Alzheimer's disease is associated with genes involved in microglial function. Inositol polyphosphate‐5‐phosphatase (INPP5D), which encodes Src homology 2 (SH2) domain–containing inositol polyphosphate 5‐phosphatase 1 (SHIP1), is a risk gene expressed in micr...

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Autores principales: Jesudason, Cynthia D., Mason, Emily R., Chu, Shaoyou, Oblak, Adrian L., Javens‐Wolfe, June, Moussaif, Mustapha, Durst, Greg, Hipskind, Philip, Beck, Daniel E., Dong, Jiajun, Amarasinghe, Ovini, Zhang, Zhong‐Yin, Hamdani, Adam K., Singhal, Kratika, Mesecar, Andrew D., Souza, Sarah, Jacobson, Marlene, Salvo, Jerry Di, Soni, Disha M., Kandasamy, Murugesh, Masters, Andrea R., Quinney, Sara K, Doolen, Suzanne, Huhe, Hasi, Rizzo, Stacey J. Sukoff, Lamb, Bruce T., Palkowitz, Alan D., Richardson, Timothy I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10655782/
https://www.ncbi.nlm.nih.gov/pubmed/38023622
http://dx.doi.org/10.1002/trc2.12429

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