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Activated PI3K delta syndrome 1 mutations cause neutrophilia in zebrafish larvae

People with activated PI3 kinase delta syndrome 1 (APDS1) suffer from immune deficiency and severe bronchiectasis. APDS1 is caused by dominant activating mutations of the PIK3CD gene that encodes the PI3 kinase delta (PI3Kδ) catalytic subunit. Despite the importance of innate immunity defects in bro...

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Detalles Bibliográficos
Autores principales:	Elworthy, Stone, Rutherford, Holly A., Prajsnar, Tomasz K., Hamilton, Noémie M., Vogt, Katja, Renshaw, Stephen A., Condliffe, Alison M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Company of Biologists Ltd 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10655814/ https://www.ncbi.nlm.nih.gov/pubmed/36805642 http://dx.doi.org/10.1242/dmm.049841

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