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Methods for mediation analysis with high-dimensional DNA methylation data: Possible choices and comparisons

Epigenetic researchers often evaluate DNA methylation as a potential mediator of the effect of social/environmental exposures on a health outcome. Modern statistical methods for jointly evaluating many mediators have not been widely adopted. We compare seven methods for high-dimensional mediation an...

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Detalles Bibliográficos
Autores principales:	Clark-Boucher, Dylan, Zhou, Xiang, Du, Jiacong, Liu, Yongmei, Needham, Belinda L., Smith, Jennifer A., Mukherjee, Bhramar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10655967/ https://www.ncbi.nlm.nih.gov/pubmed/37934796 http://dx.doi.org/10.1371/journal.pgen.1011022

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