Leukotriene A4 hydrolase inhibition improves age-related cognitive decline via modulation of synaptic function

Leukotrienes, a class of inflammatory bioactive lipids, are well studied in the periphery, but less is known of their importance in the brain. We identified that the enzyme leukotriene A4 hydrolase (LTA4H) is expressed in healthy mouse neurons, and inhibition of LTA4H in aged mice improves hippocamp...

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Detalles Bibliográficos
Autores principales: Adams, Julia M., Rege, Sanket V., Liu, Angela T., Vu, Ninh V., Raina, Sharda, Kirsher, Douglas Y., Nguyen, Amy L., Harish, Reema, Szoke, Balazs, Leone, Dino P., Czirr, Eva, Braithwaite, Steven, Kerrisk Campbell, Meghan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10656077/
https://www.ncbi.nlm.nih.gov/pubmed/37976357
http://dx.doi.org/10.1126/sciadv.adf8764

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