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Evaluation of Thiol Disulfide Homeostasis and Ischemia-Modified Albumin Levels as an Indicator of Oxidative Stress in Acne Vulgaris

INTRODUCTION: Acne vulgaris (AV) is the most common skin disease. AV is a skin disease often associated with oxidative stress. Thiols and ischemia modified albumin (IMA) analysis are used as oxidative stress markers. OBJECTIVES: In this study, it was aimed to evaluate the blood levels of thiols and...

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Autores principales: Balık, Zeynep Büşra, Balık, Ahmet Rıfat, Oğuz, Esra Fırat, Erel, Özcan, Tunca, Mustafa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mattioli 1885 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10656155/
https://www.ncbi.nlm.nih.gov/pubmed/37823854
http://dx.doi.org/10.5826/dpc.1304a280
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author Balık, Zeynep Büşra
Balık, Ahmet Rıfat
Oğuz, Esra Fırat
Erel, Özcan
Tunca, Mustafa
author_facet Balık, Zeynep Büşra
Balık, Ahmet Rıfat
Oğuz, Esra Fırat
Erel, Özcan
Tunca, Mustafa
author_sort Balık, Zeynep Büşra
collection PubMed
description INTRODUCTION: Acne vulgaris (AV) is the most common skin disease. AV is a skin disease often associated with oxidative stress. Thiols and ischemia modified albumin (IMA) analysis are used as oxidative stress markers. OBJECTIVES: In this study, it was aimed to evaluate the blood levels of thiols and IMA, which are accepted as oxidative stress markers, and to determine the severity of the disease in AV patients whose severity is determined by the global acne score rate (GAS). METHODS: Thiol parameters and IMA values were measured spectrophotometrically in blood samples taken from patients and controls. Determine GAS values in AV patients. The thiol and IMA values obtained were compared between the patient and control groups and their correlation with the patient’s GAS values was evaluated. RESULTS: In our study, in acne patients, native thiol (NT), total thiol (TT) and index 3 (I3=NT/TT*100) were significantly lower than the control group, disulfide (SS), index 1 (I1=SS/NT*100), index 2 (I2=SS/TT*100) and IMA values were found to be significantly higher. GAS values, which are accepted as an indicator of the degree and severity of acne disease, and SS, I1 and I2 showed a positive correlation, while I3 showed a negative correlation. CONCLUSIONS: Our study suggests that oxidative stress associated with AV disease pathogenesis may occur through mechanisms dependent on thiol and IMA levels. Therefore, in AV, oral supplementation or topical application of antioxidants may be a good way to increase drug efficacy or prevent potential harm.
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spelling pubmed-106561552023-10-01 Evaluation of Thiol Disulfide Homeostasis and Ischemia-Modified Albumin Levels as an Indicator of Oxidative Stress in Acne Vulgaris Balık, Zeynep Büşra Balık, Ahmet Rıfat Oğuz, Esra Fırat Erel, Özcan Tunca, Mustafa Dermatol Pract Concept Original Article INTRODUCTION: Acne vulgaris (AV) is the most common skin disease. AV is a skin disease often associated with oxidative stress. Thiols and ischemia modified albumin (IMA) analysis are used as oxidative stress markers. OBJECTIVES: In this study, it was aimed to evaluate the blood levels of thiols and IMA, which are accepted as oxidative stress markers, and to determine the severity of the disease in AV patients whose severity is determined by the global acne score rate (GAS). METHODS: Thiol parameters and IMA values were measured spectrophotometrically in blood samples taken from patients and controls. Determine GAS values in AV patients. The thiol and IMA values obtained were compared between the patient and control groups and their correlation with the patient’s GAS values was evaluated. RESULTS: In our study, in acne patients, native thiol (NT), total thiol (TT) and index 3 (I3=NT/TT*100) were significantly lower than the control group, disulfide (SS), index 1 (I1=SS/NT*100), index 2 (I2=SS/TT*100) and IMA values were found to be significantly higher. GAS values, which are accepted as an indicator of the degree and severity of acne disease, and SS, I1 and I2 showed a positive correlation, while I3 showed a negative correlation. CONCLUSIONS: Our study suggests that oxidative stress associated with AV disease pathogenesis may occur through mechanisms dependent on thiol and IMA levels. Therefore, in AV, oral supplementation or topical application of antioxidants may be a good way to increase drug efficacy or prevent potential harm. Mattioli 1885 2023-10-01 /pmc/articles/PMC10656155/ /pubmed/37823854 http://dx.doi.org/10.5826/dpc.1304a280 Text en ©2023 Balık et al. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (BY-NC-4.0), https://creativecommons.org/licenses/by-nc/4.0/, which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original authors and source are credited.
spellingShingle Original Article
Balık, Zeynep Büşra
Balık, Ahmet Rıfat
Oğuz, Esra Fırat
Erel, Özcan
Tunca, Mustafa
Evaluation of Thiol Disulfide Homeostasis and Ischemia-Modified Albumin Levels as an Indicator of Oxidative Stress in Acne Vulgaris
title Evaluation of Thiol Disulfide Homeostasis and Ischemia-Modified Albumin Levels as an Indicator of Oxidative Stress in Acne Vulgaris
title_full Evaluation of Thiol Disulfide Homeostasis and Ischemia-Modified Albumin Levels as an Indicator of Oxidative Stress in Acne Vulgaris
title_fullStr Evaluation of Thiol Disulfide Homeostasis and Ischemia-Modified Albumin Levels as an Indicator of Oxidative Stress in Acne Vulgaris
title_full_unstemmed Evaluation of Thiol Disulfide Homeostasis and Ischemia-Modified Albumin Levels as an Indicator of Oxidative Stress in Acne Vulgaris
title_short Evaluation of Thiol Disulfide Homeostasis and Ischemia-Modified Albumin Levels as an Indicator of Oxidative Stress in Acne Vulgaris
title_sort evaluation of thiol disulfide homeostasis and ischemia-modified albumin levels as an indicator of oxidative stress in acne vulgaris
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10656155/
https://www.ncbi.nlm.nih.gov/pubmed/37823854
http://dx.doi.org/10.5826/dpc.1304a280
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