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Cronassial Ameliorates Autoimmune Encephalomyelitis by Inhibiting Lipid Oxidation and Carbonyl Stress in the Brain and Spinal Cord of Rats

In recent years, the pathogenetic role of oxidative stress in damaging myelin cells, a precursor to the development of myelin-related diseases such as multiple sclerosis, has gained increasing significance. Experimental autoimmune encephalomyelitis (EAE) in rats serves as an experimental model for h...

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Autores principales: Ghazaryan, Gayane, Zanginyan, Hasmik, Hovsepyan, Laura, Azatyan, Artyom, Ghazaryan, Maria, Mardanyan, Lusine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10656202/
https://www.ncbi.nlm.nih.gov/pubmed/38024159
http://dx.doi.org/10.1155/2023/5552740
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author Ghazaryan, Gayane
Zanginyan, Hasmik
Hovsepyan, Laura
Azatyan, Artyom
Ghazaryan, Maria
Mardanyan, Lusine
author_facet Ghazaryan, Gayane
Zanginyan, Hasmik
Hovsepyan, Laura
Azatyan, Artyom
Ghazaryan, Maria
Mardanyan, Lusine
author_sort Ghazaryan, Gayane
collection PubMed
description In recent years, the pathogenetic role of oxidative stress in damaging myelin cells, a precursor to the development of myelin-related diseases such as multiple sclerosis, has gained increasing significance. Experimental autoimmune encephalomyelitis (EAE) in rats serves as an experimental model for human multiple sclerosis. Our study elucidates and demonstrates the antioxidant properties of Cronassial, a drug containing gangliosides, on the processes of free radical lipid oxidation and oxidative modification of proteins in the brains and spinal cords of rats with EAE. Our research results reveal an elevated production of oxidative stress products, including peroxides, hydroperoxides, and oxidized proteins, in experimental animals. This phenomenon is one of the factors contributing to myelin damage. Administering a ganglioside-containing drug normalizes the consequences of oxidative stress and inhibits the formation of reactive oxygen species. Consequently, the data obtained highlight the neuroprotective and antioxidant effects of Cronassial when administered to animals with autoimmune encephalomyelitis.
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spelling pubmed-106562022023-11-10 Cronassial Ameliorates Autoimmune Encephalomyelitis by Inhibiting Lipid Oxidation and Carbonyl Stress in the Brain and Spinal Cord of Rats Ghazaryan, Gayane Zanginyan, Hasmik Hovsepyan, Laura Azatyan, Artyom Ghazaryan, Maria Mardanyan, Lusine Biochem Res Int Research Article In recent years, the pathogenetic role of oxidative stress in damaging myelin cells, a precursor to the development of myelin-related diseases such as multiple sclerosis, has gained increasing significance. Experimental autoimmune encephalomyelitis (EAE) in rats serves as an experimental model for human multiple sclerosis. Our study elucidates and demonstrates the antioxidant properties of Cronassial, a drug containing gangliosides, on the processes of free radical lipid oxidation and oxidative modification of proteins in the brains and spinal cords of rats with EAE. Our research results reveal an elevated production of oxidative stress products, including peroxides, hydroperoxides, and oxidized proteins, in experimental animals. This phenomenon is one of the factors contributing to myelin damage. Administering a ganglioside-containing drug normalizes the consequences of oxidative stress and inhibits the formation of reactive oxygen species. Consequently, the data obtained highlight the neuroprotective and antioxidant effects of Cronassial when administered to animals with autoimmune encephalomyelitis. Hindawi 2023-11-10 /pmc/articles/PMC10656202/ /pubmed/38024159 http://dx.doi.org/10.1155/2023/5552740 Text en Copyright © 2023 Gayane Ghazaryan et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Ghazaryan, Gayane
Zanginyan, Hasmik
Hovsepyan, Laura
Azatyan, Artyom
Ghazaryan, Maria
Mardanyan, Lusine
Cronassial Ameliorates Autoimmune Encephalomyelitis by Inhibiting Lipid Oxidation and Carbonyl Stress in the Brain and Spinal Cord of Rats
title Cronassial Ameliorates Autoimmune Encephalomyelitis by Inhibiting Lipid Oxidation and Carbonyl Stress in the Brain and Spinal Cord of Rats
title_full Cronassial Ameliorates Autoimmune Encephalomyelitis by Inhibiting Lipid Oxidation and Carbonyl Stress in the Brain and Spinal Cord of Rats
title_fullStr Cronassial Ameliorates Autoimmune Encephalomyelitis by Inhibiting Lipid Oxidation and Carbonyl Stress in the Brain and Spinal Cord of Rats
title_full_unstemmed Cronassial Ameliorates Autoimmune Encephalomyelitis by Inhibiting Lipid Oxidation and Carbonyl Stress in the Brain and Spinal Cord of Rats
title_short Cronassial Ameliorates Autoimmune Encephalomyelitis by Inhibiting Lipid Oxidation and Carbonyl Stress in the Brain and Spinal Cord of Rats
title_sort cronassial ameliorates autoimmune encephalomyelitis by inhibiting lipid oxidation and carbonyl stress in the brain and spinal cord of rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10656202/
https://www.ncbi.nlm.nih.gov/pubmed/38024159
http://dx.doi.org/10.1155/2023/5552740
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