Anti-viral effect of usenamine a using SARS-CoV-2 pseudo-typed viruses

The escalating pandemic brought about by the novel SARS-CoV-2 virus is threatening global health, and thus, it is necessary to develop effective antiviral drugs. Usenamine A is a dibenzo-furan derivative separated from lichen Usnea diffracta showing broad-spectrum activity against different viruses....

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Detalles Bibliográficos
Autores principales: Li, Zijun, Lee, Joo-Eun, Cho, Namki, Yoo, Hee Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10656252/
https://www.ncbi.nlm.nih.gov/pubmed/38027904
http://dx.doi.org/10.1016/j.heliyon.2023.e21742
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author Li, Zijun
Lee, Joo-Eun
Cho, Namki
Yoo, Hee Min
author_facet Li, Zijun
Lee, Joo-Eun
Cho, Namki
Yoo, Hee Min
author_sort Li, Zijun
collection PubMed
description The escalating pandemic brought about by the novel SARS-CoV-2 virus is threatening global health, and thus, it is necessary to develop effective antiviral drugs. Usenamine A is a dibenzo-furan derivative separated from lichen Usnea diffracta showing broad-spectrum activity against different viruses. We evaluate that usenamine A has antiviral effects against novel SARS-CoV-2 Delta variant pseudotyped viruses (PVs) in A549 cells. In addition, usenamine A significantly suppresses SARS-CoV-2 PV-induced mitochondrial depolarization, elevated reactive oxygen species (ROS) levels, apoptosis, and inflammation. Usenamine A also causes the SARS-CoV-2 spike protein to become less stable. Thus, usenamine A shows potential as an antiviral drug that can provide protection against COVID-19.
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spelling pubmed-106562522023-10-28 Anti-viral effect of usenamine a using SARS-CoV-2 pseudo-typed viruses Li, Zijun Lee, Joo-Eun Cho, Namki Yoo, Hee Min Heliyon Research Article The escalating pandemic brought about by the novel SARS-CoV-2 virus is threatening global health, and thus, it is necessary to develop effective antiviral drugs. Usenamine A is a dibenzo-furan derivative separated from lichen Usnea diffracta showing broad-spectrum activity against different viruses. We evaluate that usenamine A has antiviral effects against novel SARS-CoV-2 Delta variant pseudotyped viruses (PVs) in A549 cells. In addition, usenamine A significantly suppresses SARS-CoV-2 PV-induced mitochondrial depolarization, elevated reactive oxygen species (ROS) levels, apoptosis, and inflammation. Usenamine A also causes the SARS-CoV-2 spike protein to become less stable. Thus, usenamine A shows potential as an antiviral drug that can provide protection against COVID-19. Elsevier 2023-10-28 /pmc/articles/PMC10656252/ /pubmed/38027904 http://dx.doi.org/10.1016/j.heliyon.2023.e21742 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Li, Zijun
Lee, Joo-Eun
Cho, Namki
Yoo, Hee Min
Anti-viral effect of usenamine a using SARS-CoV-2 pseudo-typed viruses
title Anti-viral effect of usenamine a using SARS-CoV-2 pseudo-typed viruses
title_full Anti-viral effect of usenamine a using SARS-CoV-2 pseudo-typed viruses
title_fullStr Anti-viral effect of usenamine a using SARS-CoV-2 pseudo-typed viruses
title_full_unstemmed Anti-viral effect of usenamine a using SARS-CoV-2 pseudo-typed viruses
title_short Anti-viral effect of usenamine a using SARS-CoV-2 pseudo-typed viruses
title_sort anti-viral effect of usenamine a using sars-cov-2 pseudo-typed viruses
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10656252/
https://www.ncbi.nlm.nih.gov/pubmed/38027904
http://dx.doi.org/10.1016/j.heliyon.2023.e21742
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AT chonamki antiviraleffectofusenamineausingsarscov2pseudotypedviruses
AT yooheemin antiviraleffectofusenamineausingsarscov2pseudotypedviruses

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