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Exploring the anticancer potential of Actinidia chinensis Planch root extracts (acRoots) on hepatocellular carcinoma: A molecular mechanism study
Hepatocellular carcinoma (HCC), ranking as the seventh most prevalent cancer worldwide, poses a significant health challenge. Actinidia chinensis Planch Root extracts (acRoots), a traditional Chinese medicine, has exhibited promising inhibitory effects on the proliferation, invasion, and migration o...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10656260/ https://www.ncbi.nlm.nih.gov/pubmed/38027882 http://dx.doi.org/10.1016/j.heliyon.2023.e21851 |
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author | Qiu, Kaijie Xia, Qing Chen, Hao Ye, Qiong Mao, Haixiang Tian, Mei Gan, Yichao Huang, Qinyuan Wang, Haibiao Duan, Shiwei |
author_facet | Qiu, Kaijie Xia, Qing Chen, Hao Ye, Qiong Mao, Haixiang Tian, Mei Gan, Yichao Huang, Qinyuan Wang, Haibiao Duan, Shiwei |
author_sort | Qiu, Kaijie |
collection | PubMed |
description | Hepatocellular carcinoma (HCC), ranking as the seventh most prevalent cancer worldwide, poses a significant health challenge. Actinidia chinensis Planch Root extracts (acRoots), a traditional Chinese medicine, has exhibited promising inhibitory effects on the proliferation, invasion, and migration of various cancer cell types. Nevertheless, its specific impact and underlying mechanisms concerning HCC remain unclear. This research aimed to elucidate the anticancer properties and potential molecular mechanisms of acRoots in the HepG2 and LM3 cell lines. Our findings demonstrate that acRoots effectively hampers the in vitro proliferation, migration, and invasion of HCC cells. Furthermore, acRoots induces apoptosis and autophagy by impeding the AKT/mTOR signaling pathway, with its inhibitory effects on cells being restored under AKT activator induction. This study, for the first time, elucidates that acRoots can suppress HepG2 and LM3 cell proliferation by blocking the Akt/mTOR pathway, thereby activating apoptosis and autophagy. These results underscore the potential of acRoots as a promising antitumor agent for HCC. |
format | Online Article Text |
id | pubmed-10656260 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-106562602023-11-02 Exploring the anticancer potential of Actinidia chinensis Planch root extracts (acRoots) on hepatocellular carcinoma: A molecular mechanism study Qiu, Kaijie Xia, Qing Chen, Hao Ye, Qiong Mao, Haixiang Tian, Mei Gan, Yichao Huang, Qinyuan Wang, Haibiao Duan, Shiwei Heliyon Research Article Hepatocellular carcinoma (HCC), ranking as the seventh most prevalent cancer worldwide, poses a significant health challenge. Actinidia chinensis Planch Root extracts (acRoots), a traditional Chinese medicine, has exhibited promising inhibitory effects on the proliferation, invasion, and migration of various cancer cell types. Nevertheless, its specific impact and underlying mechanisms concerning HCC remain unclear. This research aimed to elucidate the anticancer properties and potential molecular mechanisms of acRoots in the HepG2 and LM3 cell lines. Our findings demonstrate that acRoots effectively hampers the in vitro proliferation, migration, and invasion of HCC cells. Furthermore, acRoots induces apoptosis and autophagy by impeding the AKT/mTOR signaling pathway, with its inhibitory effects on cells being restored under AKT activator induction. This study, for the first time, elucidates that acRoots can suppress HepG2 and LM3 cell proliferation by blocking the Akt/mTOR pathway, thereby activating apoptosis and autophagy. These results underscore the potential of acRoots as a promising antitumor agent for HCC. Elsevier 2023-11-02 /pmc/articles/PMC10656260/ /pubmed/38027882 http://dx.doi.org/10.1016/j.heliyon.2023.e21851 Text en © 2023 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Research Article Qiu, Kaijie Xia, Qing Chen, Hao Ye, Qiong Mao, Haixiang Tian, Mei Gan, Yichao Huang, Qinyuan Wang, Haibiao Duan, Shiwei Exploring the anticancer potential of Actinidia chinensis Planch root extracts (acRoots) on hepatocellular carcinoma: A molecular mechanism study |
title | Exploring the anticancer potential of Actinidia chinensis Planch root extracts (acRoots) on hepatocellular carcinoma: A molecular mechanism study |
title_full | Exploring the anticancer potential of Actinidia chinensis Planch root extracts (acRoots) on hepatocellular carcinoma: A molecular mechanism study |
title_fullStr | Exploring the anticancer potential of Actinidia chinensis Planch root extracts (acRoots) on hepatocellular carcinoma: A molecular mechanism study |
title_full_unstemmed | Exploring the anticancer potential of Actinidia chinensis Planch root extracts (acRoots) on hepatocellular carcinoma: A molecular mechanism study |
title_short | Exploring the anticancer potential of Actinidia chinensis Planch root extracts (acRoots) on hepatocellular carcinoma: A molecular mechanism study |
title_sort | exploring the anticancer potential of actinidia chinensis planch root extracts (acroots) on hepatocellular carcinoma: a molecular mechanism study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10656260/ https://www.ncbi.nlm.nih.gov/pubmed/38027882 http://dx.doi.org/10.1016/j.heliyon.2023.e21851 |
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