Ligand-dependent hedgehog signaling maintains an undifferentiated, malignant osteosarcoma phenotype

TP53 and RB1 loss-of-function mutations are common in osteosarcoma. During development, combined loss of TP53 and RB1 function leads to downregulation of autophagy and the aberrant formation of primary cilia, cellular organelles essential for the transmission of canonical Hedgehog (Hh) signaling. Ex...

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Detalles Bibliográficos
Autores principales: Vaghjiani, Vijesh G., Cochrane, Catherine R., Jayasekara, W. Samantha N., Chong, Wai Chin, Szczepny, Anette, Kumar, Beena, Martelotto, Luciano G., McCaw, Andrew, Carey, Kirstyn, Kansara, Maya, Thomas, David M., Walkley, Carl, Mudge, Stuart, Gough, Daniel J., Downie, Peter A., Peacock, Craig D., Matsui, William, Watkins, D. Neil, Cain, Jason E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10656285/
https://www.ncbi.nlm.nih.gov/pubmed/37845394
http://dx.doi.org/10.1038/s41388-023-02864-7

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