Mutant p53(R211*) ameliorates inflammatory arthritis in AIA rats via inhibition of TBK1-IRF3 innate immune response

BACKGROUND: Rheumatoid arthritis (RA) is an autoimmune inflammation disease characterized by imbalance of immune homeostasis. p53 mutants are commonly described as the guardian of cancer cells by conferring them drug-resistance and immune evasion. Importantly, p53 mutations have also been identified...

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Detalles Bibliográficos
Autores principales: Zeng, Yaling, Ng, Jerome P. L., Wang, Linna, Xu, Xiongfei, Law, Betty Yuen Kwan, Chen, Guobing, Lo, Hang Hong, Yang, Lijun, Yang, Jiujie, Zhang, Lei, Qu, Liqun, Yun, Xiaoyun, Zhong, Jing, Chen, Ruihong, Zhang, Dingqi, Wang, Yuping, Luo, Weidan, Qiu, Congling, Huang, Baixiong, liu, Wenfeng, Liu, Liang, Wong, Vincent Kam Wai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Original Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10656327/
https://www.ncbi.nlm.nih.gov/pubmed/37935918
http://dx.doi.org/10.1007/s00011-023-01809-w

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