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Identification of novel STAT3 inhibitors for liver fibrosis, using pharmacophore-based virtual screening, molecular docking, and biomolecular dynamics simulations

The signal transducer and activator of transcription 3 (STAT3) plays a fundamental role in the growth and regulation of cellular life. Activation and over-expression of STAT3 have been implicated in many cancers including solid blood tumors and other diseases such as liver fibrosis and rheumatoid ar...

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Detalles Bibliográficos
Autores principales:	Rafiq, Huma, Hu, Junjian, Hakami, Mohammed Ageeli, Hazazi, Ali, Alamri, Mubarak A., Alkhatabi, Hind A., Mahmood, Arif, Alotaibi, Bader S., Wadood, Abdul, Huang, Xiaoyun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10656421/ https://www.ncbi.nlm.nih.gov/pubmed/37978263 http://dx.doi.org/10.1038/s41598-023-46193-x

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