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Diversity of mitophagy pathways at a glance
Mitochondria are crucial organelles that play a central role in various cell signaling and metabolic pathways. A healthy mitochondrial population is maintained through a series of quality control pathways and requires a fine-tuned balance between mitochondrial biogenesis and degradation. Defective t...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Company of Biologists Ltd
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10656428/ https://www.ncbi.nlm.nih.gov/pubmed/36504076 http://dx.doi.org/10.1242/jcs.259748 |
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author | Ganley, Ian G. Simonsen, Anne |
author_facet | Ganley, Ian G. Simonsen, Anne |
author_sort | Ganley, Ian G. |
collection | PubMed |
description | Mitochondria are crucial organelles that play a central role in various cell signaling and metabolic pathways. A healthy mitochondrial population is maintained through a series of quality control pathways and requires a fine-tuned balance between mitochondrial biogenesis and degradation. Defective targeting of dysfunctional mitochondria to lysosomes through mitophagy has been linked to several diseases, but the underlying mechanisms and the relative importance of distinct mitophagy pathways in vivo are largely unknown. In this Cell Science at a Glance and the accompanying poster, we describe our current understanding of how parts of, or whole, mitochondria are recognized by the autophagic machinery and targeted to lysosomes for degradation. We also discuss how this might be regulated under different physiological conditions to maintain mitochondrial and cellular health. |
format | Online Article Text |
id | pubmed-10656428 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Company of Biologists Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-106564282022-12-12 Diversity of mitophagy pathways at a glance Ganley, Ian G. Simonsen, Anne J Cell Sci Cell Science at A Glance Mitochondria are crucial organelles that play a central role in various cell signaling and metabolic pathways. A healthy mitochondrial population is maintained through a series of quality control pathways and requires a fine-tuned balance between mitochondrial biogenesis and degradation. Defective targeting of dysfunctional mitochondria to lysosomes through mitophagy has been linked to several diseases, but the underlying mechanisms and the relative importance of distinct mitophagy pathways in vivo are largely unknown. In this Cell Science at a Glance and the accompanying poster, we describe our current understanding of how parts of, or whole, mitochondria are recognized by the autophagic machinery and targeted to lysosomes for degradation. We also discuss how this might be regulated under different physiological conditions to maintain mitochondrial and cellular health. The Company of Biologists Ltd 2022-12-12 /pmc/articles/PMC10656428/ /pubmed/36504076 http://dx.doi.org/10.1242/jcs.259748 Text en © 2022. Published by The Company of Biologists Ltd https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. |
spellingShingle | Cell Science at A Glance Ganley, Ian G. Simonsen, Anne Diversity of mitophagy pathways at a glance |
title | Diversity of mitophagy pathways at a glance |
title_full | Diversity of mitophagy pathways at a glance |
title_fullStr | Diversity of mitophagy pathways at a glance |
title_full_unstemmed | Diversity of mitophagy pathways at a glance |
title_short | Diversity of mitophagy pathways at a glance |
title_sort | diversity of mitophagy pathways at a glance |
topic | Cell Science at A Glance |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10656428/ https://www.ncbi.nlm.nih.gov/pubmed/36504076 http://dx.doi.org/10.1242/jcs.259748 |
work_keys_str_mv | AT ganleyiang diversityofmitophagypathwaysataglance AT simonsenanne diversityofmitophagypathwaysataglance |