GDF11 slows excitatory neuronal senescence and brain ageing by repressing p21

As a major neuron type in the brain, the excitatory neuron (EN) regulates the lifespan in C. elegans. How the EN acquires senescence, however, is unknown. Here, we show that growth differentiation factor 11 (GDF11) is predominantly expressed in the EN in the adult mouse, marmoset and human brain. In...

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Detalles Bibliográficos
Autores principales: Wang, Di-Xian, Dong, Zhao-Jun, Deng, Sui-Xin, Tian, Ying-Ming, Xiao, Yu-Jie, Li, Xinran, Ma, Xiao-Ru, Li, Liang, Li, Pengxiao, Chang, Hui-Zhong, Liu, Longqi, Wang, Fan, Wu, Yang, Gao, Xiang, Zheng, Shuang-Shuang, Gu, Hui-Min, Zhang, Ya-Nan, Wu, Jian-Bin, Wu, Fan, Peng, Yonglin, Zhang, Xiao-Wen, Zhan, Ren-Ya, Gao, Li-Xia, Sun, Qiming, Guo, Xing, Zhao, Xiao-Dong, Luo, Jian-Hong, Zhou, Ruhong, Han, Lei, Shu, Yousheng, Zhao, Jing-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10656444/
https://www.ncbi.nlm.nih.gov/pubmed/37978295
http://dx.doi.org/10.1038/s41467-023-43292-1

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