Modeling phenotypic heterogeneity towards evolutionarily inspired osteosarcoma therapy

Osteosarcoma is the most common bone sarcoma in children and young adults. While universally delivered, chemotherapy only benefits roughly half of patients with localized disease. Increasingly, intratumoral heterogeneity is recognized as a source of therapeutic resistance. In this study, we develop...

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Detalles Bibliográficos
Autores principales: Welch, Darcy L., Fridley, Brooke L., Cen, Ling, Teer, Jamie K., Yoder, Sean J., Pettersson, Fredrik, Xu, Liping, Cheng, Chia-Ho, Zhang, Yonghong, Alexandrow, Mark G., Xiang, Shengyan, Robertson-Tessi, Mark, Brown, Joel S., Metts, Jonathan, Brohl, Andrew S., Reed, Damon R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10656496/
https://www.ncbi.nlm.nih.gov/pubmed/37978271
http://dx.doi.org/10.1038/s41598-023-47412-1

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