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Use of magnetic source imaging to assess recovery after severe traumatic brain injury—an MEG pilot study

RATIONALE: Severe TBI (sTBI) is a devastating neurological injury that comprises a significant global trauma burden. Early comprehensive neurocritical care and rehabilitation improve outcomes for such patients, although better diagnostic and prognostic tools are necessary to guide personalized treat...

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Autores principales: Sarma, Anand Karthik, Popli, Gautam, Anzalone, Anthony, Contillo, Nicholas, Cornell, Cassandra, Nunn, Andrew M., Rowland, Jared A., Godwin, Dwayne W., Flashman, Laura A., Couture, Daniel, Stapleton-Kotloski, Jennifer R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10656620/
https://www.ncbi.nlm.nih.gov/pubmed/38020602
http://dx.doi.org/10.3389/fneur.2023.1257886
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author Sarma, Anand Karthik
Popli, Gautam
Anzalone, Anthony
Contillo, Nicholas
Cornell, Cassandra
Nunn, Andrew M.
Rowland, Jared A.
Godwin, Dwayne W.
Flashman, Laura A.
Couture, Daniel
Stapleton-Kotloski, Jennifer R.
author_facet Sarma, Anand Karthik
Popli, Gautam
Anzalone, Anthony
Contillo, Nicholas
Cornell, Cassandra
Nunn, Andrew M.
Rowland, Jared A.
Godwin, Dwayne W.
Flashman, Laura A.
Couture, Daniel
Stapleton-Kotloski, Jennifer R.
author_sort Sarma, Anand Karthik
collection PubMed
description RATIONALE: Severe TBI (sTBI) is a devastating neurological injury that comprises a significant global trauma burden. Early comprehensive neurocritical care and rehabilitation improve outcomes for such patients, although better diagnostic and prognostic tools are necessary to guide personalized treatment plans. METHODS: In this study, we explored the feasibility of conducting resting state magnetoencephalography (MEG) in a case series of sTBI patients acutely after injury (~7 days), and then about 1.5 and 8 months after injury. Synthetic aperture magnetometry (SAM) was utilized to localize source power in the canonical frequency bands of delta, theta, alpha, beta, and gamma, as well as DC–80 Hz. RESULTS: At the first scan, SAM source maps revealed zones of hypofunction, islands of preserved activity, and hemispheric asymmetry across bandwidths, with markedly reduced power on the side of injury for each patient. GCS scores improved at scan 2 and by scan 3 the patients were ambulatory. The SAM maps for scans 2 and 3 varied, with most patients showing increasing power over time, especially in gamma, but a continued reduction in power in damaged areas and hemispheric asymmetry and/or relative diminishment in power at the site of injury. At the group level for scan 1, there was a large excess of neural generators operating within the delta band relative to control participants, while the number of neural generators for beta and gamma were significantly reduced. At scan 2 there was increased beta power relative to controls. At scan 3 there was increased group-wise delta power in comparison to controls. CONCLUSION: In summary, this pilot study shows that MEG can be safely used to monitor and track the recovery of brain function in patients with severe TBI as well as to identify patient-specific regions of decreased or altered brain function. Such MEG maps of brain function may be used in the future to tailor patient-specific rehabilitation plans to target regions of altered spectral power with neurostimulation and other treatments.
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spelling pubmed-106566202023-11-03 Use of magnetic source imaging to assess recovery after severe traumatic brain injury—an MEG pilot study Sarma, Anand Karthik Popli, Gautam Anzalone, Anthony Contillo, Nicholas Cornell, Cassandra Nunn, Andrew M. Rowland, Jared A. Godwin, Dwayne W. Flashman, Laura A. Couture, Daniel Stapleton-Kotloski, Jennifer R. Front Neurol Neurology RATIONALE: Severe TBI (sTBI) is a devastating neurological injury that comprises a significant global trauma burden. Early comprehensive neurocritical care and rehabilitation improve outcomes for such patients, although better diagnostic and prognostic tools are necessary to guide personalized treatment plans. METHODS: In this study, we explored the feasibility of conducting resting state magnetoencephalography (MEG) in a case series of sTBI patients acutely after injury (~7 days), and then about 1.5 and 8 months after injury. Synthetic aperture magnetometry (SAM) was utilized to localize source power in the canonical frequency bands of delta, theta, alpha, beta, and gamma, as well as DC–80 Hz. RESULTS: At the first scan, SAM source maps revealed zones of hypofunction, islands of preserved activity, and hemispheric asymmetry across bandwidths, with markedly reduced power on the side of injury for each patient. GCS scores improved at scan 2 and by scan 3 the patients were ambulatory. The SAM maps for scans 2 and 3 varied, with most patients showing increasing power over time, especially in gamma, but a continued reduction in power in damaged areas and hemispheric asymmetry and/or relative diminishment in power at the site of injury. At the group level for scan 1, there was a large excess of neural generators operating within the delta band relative to control participants, while the number of neural generators for beta and gamma were significantly reduced. At scan 2 there was increased beta power relative to controls. At scan 3 there was increased group-wise delta power in comparison to controls. CONCLUSION: In summary, this pilot study shows that MEG can be safely used to monitor and track the recovery of brain function in patients with severe TBI as well as to identify patient-specific regions of decreased or altered brain function. Such MEG maps of brain function may be used in the future to tailor patient-specific rehabilitation plans to target regions of altered spectral power with neurostimulation and other treatments. Frontiers Media S.A. 2023-11-03 /pmc/articles/PMC10656620/ /pubmed/38020602 http://dx.doi.org/10.3389/fneur.2023.1257886 Text en Copyright © 2023 Sarma, Popli, Anzalone, Contillo, Cornell, Nunn, Rowland, Godwin, Flashman, Couture and Stapleton-Kotloski. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Sarma, Anand Karthik
Popli, Gautam
Anzalone, Anthony
Contillo, Nicholas
Cornell, Cassandra
Nunn, Andrew M.
Rowland, Jared A.
Godwin, Dwayne W.
Flashman, Laura A.
Couture, Daniel
Stapleton-Kotloski, Jennifer R.
Use of magnetic source imaging to assess recovery after severe traumatic brain injury—an MEG pilot study
title Use of magnetic source imaging to assess recovery after severe traumatic brain injury—an MEG pilot study
title_full Use of magnetic source imaging to assess recovery after severe traumatic brain injury—an MEG pilot study
title_fullStr Use of magnetic source imaging to assess recovery after severe traumatic brain injury—an MEG pilot study
title_full_unstemmed Use of magnetic source imaging to assess recovery after severe traumatic brain injury—an MEG pilot study
title_short Use of magnetic source imaging to assess recovery after severe traumatic brain injury—an MEG pilot study
title_sort use of magnetic source imaging to assess recovery after severe traumatic brain injury—an meg pilot study
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10656620/
https://www.ncbi.nlm.nih.gov/pubmed/38020602
http://dx.doi.org/10.3389/fneur.2023.1257886
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