A case of radiotherapy-induced bullous pemphigoid with unusually delayed onset: A case report

Bullous pemphigoid is an auto-immune blistering disease that generally affects older patients. Radiotherapy is one of the many triggering factors that have been described. Time to disease onset is variable; cases have been described during the course of radiotherapy while others have occurred up to...

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Detalles Bibliográficos
Autores principales: El Barch, Maha, Davar, Sandra, Bélisle, Annie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2023
Materias:
JCMS Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10656799/
https://www.ncbi.nlm.nih.gov/pubmed/38022852
http://dx.doi.org/10.1177/2050313X231212991
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author El Barch, Maha
Davar, Sandra
Bélisle, Annie
author_facet El Barch, Maha
Davar, Sandra
Bélisle, Annie
author_sort El Barch, Maha
collection PubMed
description Bullous pemphigoid is an auto-immune blistering disease that generally affects older patients. Radiotherapy is one of the many triggering factors that have been described. Time to disease onset is variable; cases have been described during the course of radiotherapy while others have occurred up to 9 years later. We report a case of localized bullous pemphigoid on an irradiated site with unusual late presentation, 25 years after radiotherapy for left breast cancer. The pathophysiology of radiation-induced bullous pemphigoid is not clear, but the concept of an immunocompromised district seems to be a plausible explanation for the delayed onset of the disease.
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spelling pubmed-106567992023-11-16 A case of radiotherapy-induced bullous pemphigoid with unusually delayed onset: A case report El Barch, Maha Davar, Sandra Bélisle, Annie SAGE Open Med Case Rep JCMS Case Reports Bullous pemphigoid is an auto-immune blistering disease that generally affects older patients. Radiotherapy is one of the many triggering factors that have been described. Time to disease onset is variable; cases have been described during the course of radiotherapy while others have occurred up to 9 years later. We report a case of localized bullous pemphigoid on an irradiated site with unusual late presentation, 25 years after radiotherapy for left breast cancer. The pathophysiology of radiation-induced bullous pemphigoid is not clear, but the concept of an immunocompromised district seems to be a plausible explanation for the delayed onset of the disease. SAGE Publications 2023-11-16 /pmc/articles/PMC10656799/ /pubmed/38022852 http://dx.doi.org/10.1177/2050313X231212991 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle JCMS Case Reports
El Barch, Maha
Davar, Sandra
Bélisle, Annie
A case of radiotherapy-induced bullous pemphigoid with unusually delayed onset: A case report
title A case of radiotherapy-induced bullous pemphigoid with unusually delayed onset: A case report
title_full A case of radiotherapy-induced bullous pemphigoid with unusually delayed onset: A case report
title_fullStr A case of radiotherapy-induced bullous pemphigoid with unusually delayed onset: A case report
title_full_unstemmed A case of radiotherapy-induced bullous pemphigoid with unusually delayed onset: A case report
title_short A case of radiotherapy-induced bullous pemphigoid with unusually delayed onset: A case report
title_sort case of radiotherapy-induced bullous pemphigoid with unusually delayed onset: a case report
topic JCMS Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10656799/
https://www.ncbi.nlm.nih.gov/pubmed/38022852
http://dx.doi.org/10.1177/2050313X231212991
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