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Is Serum Uric Acid Level Associated with Disease Activity in Rheumatoid Arthritis Patients
BACKGROUND: An association between serum uric acid (UA) and disease activity in rheumatoid arthritis (RA) patients has not been well studied. We describe RA patients with high and normal UA and study its association with RA activity. METHODS: Adult RA patients from the Kuwait Registry for Rheumatic...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10656862/ https://www.ncbi.nlm.nih.gov/pubmed/38026718 http://dx.doi.org/10.2147/OARRR.S418814 |
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author | Alkhudir, Dalal Al-Herz, Adeeba Saleh, Khulood Alawadhi, Adel Al-Kandari, Waleed Hasan, Eman Mokaddem, Khaled Ghanem, Aqeel Bartella, Youssef Attia Hussain, Mohammed AlHadhood, Naser Ali, Yaser Nahar, Ebrahim Alenizi, Ahmad Aldei, Ali Abutiban, Fatemah Hayat, Sawsan Behbehani, Hussain Baron, Fatemah Alhajeri, Hebah Alkadi, Amjad Alsaber, Ahmed |
author_facet | Alkhudir, Dalal Al-Herz, Adeeba Saleh, Khulood Alawadhi, Adel Al-Kandari, Waleed Hasan, Eman Mokaddem, Khaled Ghanem, Aqeel Bartella, Youssef Attia Hussain, Mohammed AlHadhood, Naser Ali, Yaser Nahar, Ebrahim Alenizi, Ahmad Aldei, Ali Abutiban, Fatemah Hayat, Sawsan Behbehani, Hussain Baron, Fatemah Alhajeri, Hebah Alkadi, Amjad Alsaber, Ahmed |
author_sort | Alkhudir, Dalal |
collection | PubMed |
description | BACKGROUND: An association between serum uric acid (UA) and disease activity in rheumatoid arthritis (RA) patients has not been well studied. We describe RA patients with high and normal UA and study its association with RA activity. METHODS: Adult RA patients from the Kuwait Registry for Rheumatic Diseases (KRRD) were studied from February 2012 through March 2022. Patients with documented UA levels were included. UA of >357 µmol/L (6mg/dL) was considered high. Statistical comparison and correlation were made using multivariate logistic regression. RESULTS: Overall, 1054 patients with documented UA. A total of 158 patients (15%) had high UA level with a mean of 409± 44.4µmol/L. The mean age for the high UA group and low UA group were 59.3 ± 10.7 years and 54.5 ± 12.4 years, respectively (p<0.001). 49.4% were female in high UA group, and 62.2% were female in low UA group, respectively (p<0.05). Logistic analysis showed an inverse relation between DAS28 and UA, as lower DAS28 score was associated with higher UA level (p=0.032) OR 1.39. There was a direct relation with HAQ, creatinine and UA. A higher HAQ is associated with a higher UA level (p=0.019) OR 0.78. High creatinine level is also associated with high UA level (p<0.001) OR 0.24. The use of antirheumatic drugs was similar among patients with high and normal UA. CONCLUSION: RA patients with a higher UA had a lower disease activity despite using similar antirheumatic drugs. The reasons behind this association need to be further studied. |
format | Online Article Text |
id | pubmed-10656862 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-106568622023-11-14 Is Serum Uric Acid Level Associated with Disease Activity in Rheumatoid Arthritis Patients Alkhudir, Dalal Al-Herz, Adeeba Saleh, Khulood Alawadhi, Adel Al-Kandari, Waleed Hasan, Eman Mokaddem, Khaled Ghanem, Aqeel Bartella, Youssef Attia Hussain, Mohammed AlHadhood, Naser Ali, Yaser Nahar, Ebrahim Alenizi, Ahmad Aldei, Ali Abutiban, Fatemah Hayat, Sawsan Behbehani, Hussain Baron, Fatemah Alhajeri, Hebah Alkadi, Amjad Alsaber, Ahmed Open Access Rheumatol Original Research BACKGROUND: An association between serum uric acid (UA) and disease activity in rheumatoid arthritis (RA) patients has not been well studied. We describe RA patients with high and normal UA and study its association with RA activity. METHODS: Adult RA patients from the Kuwait Registry for Rheumatic Diseases (KRRD) were studied from February 2012 through March 2022. Patients with documented UA levels were included. UA of >357 µmol/L (6mg/dL) was considered high. Statistical comparison and correlation were made using multivariate logistic regression. RESULTS: Overall, 1054 patients with documented UA. A total of 158 patients (15%) had high UA level with a mean of 409± 44.4µmol/L. The mean age for the high UA group and low UA group were 59.3 ± 10.7 years and 54.5 ± 12.4 years, respectively (p<0.001). 49.4% were female in high UA group, and 62.2% were female in low UA group, respectively (p<0.05). Logistic analysis showed an inverse relation between DAS28 and UA, as lower DAS28 score was associated with higher UA level (p=0.032) OR 1.39. There was a direct relation with HAQ, creatinine and UA. A higher HAQ is associated with a higher UA level (p=0.019) OR 0.78. High creatinine level is also associated with high UA level (p<0.001) OR 0.24. The use of antirheumatic drugs was similar among patients with high and normal UA. CONCLUSION: RA patients with a higher UA had a lower disease activity despite using similar antirheumatic drugs. The reasons behind this association need to be further studied. Dove 2023-11-14 /pmc/articles/PMC10656862/ /pubmed/38026718 http://dx.doi.org/10.2147/OARRR.S418814 Text en © 2023 Alkhudir et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Alkhudir, Dalal Al-Herz, Adeeba Saleh, Khulood Alawadhi, Adel Al-Kandari, Waleed Hasan, Eman Mokaddem, Khaled Ghanem, Aqeel Bartella, Youssef Attia Hussain, Mohammed AlHadhood, Naser Ali, Yaser Nahar, Ebrahim Alenizi, Ahmad Aldei, Ali Abutiban, Fatemah Hayat, Sawsan Behbehani, Hussain Baron, Fatemah Alhajeri, Hebah Alkadi, Amjad Alsaber, Ahmed Is Serum Uric Acid Level Associated with Disease Activity in Rheumatoid Arthritis Patients |
title | Is Serum Uric Acid Level Associated with Disease Activity in Rheumatoid Arthritis Patients |
title_full | Is Serum Uric Acid Level Associated with Disease Activity in Rheumatoid Arthritis Patients |
title_fullStr | Is Serum Uric Acid Level Associated with Disease Activity in Rheumatoid Arthritis Patients |
title_full_unstemmed | Is Serum Uric Acid Level Associated with Disease Activity in Rheumatoid Arthritis Patients |
title_short | Is Serum Uric Acid Level Associated with Disease Activity in Rheumatoid Arthritis Patients |
title_sort | is serum uric acid level associated with disease activity in rheumatoid arthritis patients |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10656862/ https://www.ncbi.nlm.nih.gov/pubmed/38026718 http://dx.doi.org/10.2147/OARRR.S418814 |
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